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pubmed-article:18838388pubmed:abstractTextIL-1 has a central role mediating inflammation and joint destruction in RA. Single nucleotide polymorphisms (SNPs) and haplotype structure in the promoter region can modulate IL-1 function. This study examined the effects of four common promoter SNPs in the IL-1 region on susceptibility and clinical characteristics of RA in British Caucasian patients and assessed the risk of RA by meta-analysis of published studies.lld:pubmed
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pubmed-article:18838388pubmed:articleTitleInterleukin-1 promoter region polymorphism role in rheumatoid arthritis: a meta-analysis of IL-1B-511A/G variant reveals association with rheumatoid arthritis.lld:pubmed
pubmed-article:18838388pubmed:affiliationBotnar Research Centre, Nuffield Orthopaedic Centre, Windmill Road, Oxford OX3 7LD, UK. pille.harrison@ndos.ox.ac.uklld:pubmed
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