Linked Life Data

18838301

Source:http://linkedlifedata.com/resource/pubmed/id/18838301

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2009-3-23
pubmed:abstractText
In mammals, the gut is populated with an extremely dense and diverse bacterial community. One response following intestinal colonization is the production of immunoglobulin (Ig) A by B cells present in the gut-associated lymphoid tissues (GALT). In this review, we summarize recent advances in our understanding of the sites, mechanisms, and functions of intestinal IgA synthesis. We discuss here the pathways leading to IgA production, in organized structures as well as nonorganized tissues, by T-dependent as well as T-independent mechanisms. In addition, we discuss new insights into the role of gut IgA in the regulation of bacterial communities and maintenance of immune homeostasis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1471-4906
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
523-31
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
How host-bacterial interactions lead to IgA synthesis in the gut.
pubmed:affiliation
Laboratory for Mucosal Immunity, RIKEN Research Center for Allergy and Immunology, 230-0045 Tsurumi, Yokohama, Japan. suzukike@rcai.riken.jp
pubmed:publicationType
Journal Article, Review