|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006968,
umls-concept:C0026336,
umls-concept:C0031327,
umls-concept:C0033809,
umls-concept:C0035243,
umls-concept:C0205191,
umls-concept:C0205314,
umls-concept:C0591833,
umls-concept:C0679622,
umls-concept:C1515655,
umls-concept:C1527650,
umls-concept:C2699965
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|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2008-11-17
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|
pubmed:abstractText |
Tomopenem (CS-023) is a novel parenteral carbapenem with broad-spectrum activity against Gram-positive and -negative bacteria, as well as potent activity against drug-resistant pathogens, including penicillin-resistant Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. We compared the in vivo activity of tomopenem and that of meropenem in a chronic lower respiratory infection mouse model of P. aeruginosa.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
1460-2091
|
|
pubmed:author |
pubmed-author:IzumikawaKoichiK,
pubmed-author:KakeyaHiroshiH,
pubmed-author:KamihiraShimeruS,
pubmed-author:KohnoShigeruS,
pubmed-author:MorinagaYoshitomoY,
pubmed-author:NakamuraShigekiS,
pubmed-author:SekiMasafumiM,
pubmed-author:YamadaYasuakiY,
pubmed-author:YamamotoKazukoK,
pubmed-author:YamamotoYoshihiroY,
pubmed-author:YanagiharaKatsunoriK
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|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
62
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1326-31
|
|
pubmed:meshHeading |
pubmed-meshheading:18835805-Animals,
pubmed-meshheading:18835805-Anti-Bacterial Agents,
pubmed-meshheading:18835805-Carbapenems,
pubmed-meshheading:18835805-Colony Count, Microbial,
pubmed-meshheading:18835805-Humans,
pubmed-meshheading:18835805-Lung,
pubmed-meshheading:18835805-Male,
pubmed-meshheading:18835805-Mice,
pubmed-meshheading:18835805-Pseudomonas Infections,
pubmed-meshheading:18835805-Pseudomonas aeruginosa,
pubmed-meshheading:18835805-Respiratory Tract Infections,
pubmed-meshheading:18835805-Serum,
pubmed-meshheading:18835805-Thienamycins
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|
pubmed:year |
2008
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|
pubmed:articleTitle |
In vivo efficacy and pharmacokinetics of tomopenem (CS-023), a novel carbapenem, against Pseudomonas aeruginosa in a murine chronic respiratory tract infection model.
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|
pubmed:affiliation |
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
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|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
