| pubmed-article:18832467 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18832467 | lifeskim:mentions | umls-concept:C0080298 | lld:lifeskim |
| pubmed-article:18832467 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:18832467 | lifeskim:mentions | umls-concept:C0027627 | lld:lifeskim |
| pubmed-article:18832467 | lifeskim:mentions | umls-concept:C1513095 | lld:lifeskim |
| pubmed-article:18832467 | lifeskim:mentions | umls-concept:C1721040 | lld:lifeskim |
| pubmed-article:18832467 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:18832467 | pubmed:issue | 41 | lld:pubmed |
| pubmed-article:18832467 | pubmed:dateCreated | 2008-10-16 | lld:pubmed |
| pubmed-article:18832467 | pubmed:abstractText | The scaffold PDZ-domain containing protein mda-9/syntenin functions as a positive regulator of cancer cell progression in human melanoma and other tumors. mda-9/Syntenin regulates cell motility and invasion by altering defined biochemical and signaling pathways, including focal adhesion kinase (FAK), p38 mitogen-activated protein kinase (MAPK) and NF-kappaB, but precisely how mda-9/syntenin organizes these multiprotein signaling complexes is not well understood. Using a clinically relevant human melanoma model, we demonstrate that mda-9/syntenin physically interacts with c-Src and this communication correlates with an increase in FAK/c-Src complex formation and c-Src activation. Inhibiting mda-9/syntenin, using an adenovirus expressing antisense mda-9/syntenin or addition of c-Src siRNA, suppresses melanoma cell migration, anchorage-independent growth, and spontaneous tumor cell dissemination in vivo in a human melanoma animal metastasis model. These data are compatible with a model wherein interaction of MDA-9/syntenin with c-Src promotes the formation of an active FAK/c-Src signaling complex, leading to enhanced tumor cell invasion and metastatic spread. These provocative findings highlight mda-9/syntenin and its interacting partners as promising therapeutic targets for intervention of metastasis. | lld:pubmed |
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| pubmed-article:18832467 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:18832467 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18832467 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18832467 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:18832467 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:18832467 | pubmed:author | pubmed-author:FisherPaul... | lld:pubmed |
| pubmed-article:18832467 | pubmed:author | pubmed-author:BoukercheHabi... | lld:pubmed |
| pubmed-article:18832467 | pubmed:author | pubmed-author:SarkarDevanan... | lld:pubmed |
| pubmed-article:18832467 | pubmed:author | pubmed-author:SuZao-zhongZZ | lld:pubmed |
| pubmed-article:18832467 | pubmed:author | pubmed-author:PrévotCéliaC | lld:pubmed |
| pubmed-article:18832467 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18832467 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:18832467 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:18832467 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18832467 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18832467 | pubmed:pagination | 15914-9 | lld:pubmed |
| pubmed-article:18832467 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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| pubmed-article:18832467 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18832467 | pubmed:articleTitle | mda-9/Syntenin promotes metastasis in human melanoma cells by activating c-Src. | lld:pubmed |
| pubmed-article:18832467 | pubmed:affiliation | Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA. | lld:pubmed |
| pubmed-article:18832467 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18832467 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18832467 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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