Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
41
pubmed:dateCreated
2008-10-16
pubmed:abstractText
The scaffold PDZ-domain containing protein mda-9/syntenin functions as a positive regulator of cancer cell progression in human melanoma and other tumors. mda-9/Syntenin regulates cell motility and invasion by altering defined biochemical and signaling pathways, including focal adhesion kinase (FAK), p38 mitogen-activated protein kinase (MAPK) and NF-kappaB, but precisely how mda-9/syntenin organizes these multiprotein signaling complexes is not well understood. Using a clinically relevant human melanoma model, we demonstrate that mda-9/syntenin physically interacts with c-Src and this communication correlates with an increase in FAK/c-Src complex formation and c-Src activation. Inhibiting mda-9/syntenin, using an adenovirus expressing antisense mda-9/syntenin or addition of c-Src siRNA, suppresses melanoma cell migration, anchorage-independent growth, and spontaneous tumor cell dissemination in vivo in a human melanoma animal metastasis model. These data are compatible with a model wherein interaction of MDA-9/syntenin with c-Src promotes the formation of an active FAK/c-Src signaling complex, leading to enhanced tumor cell invasion and metastatic spread. These provocative findings highlight mda-9/syntenin and its interacting partners as promising therapeutic targets for intervention of metastasis.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-10512882, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-10702640, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-11059782, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-11114744, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-11572761, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-11992398, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-12037664, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-12371144, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-12759180, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-1381508, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-14593208, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-15246683, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-15254681, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-15380511, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-15518882, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-15688067, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-16322237, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-16728403, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-17028194, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-17308124, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-17620773, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-18451132, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-2018350, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-2431764, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-2454466, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-3338471, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-7509446, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-7537173, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-8832401, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-9442882, http://linkedlifedata.com/resource/pubmed/commentcorrection/18832467-9511750
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1091-6490
pubmed:author
pubmed:issnType
Electronic
pubmed:day
14
pubmed:volume
105
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15914-9
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
mda-9/Syntenin promotes metastasis in human melanoma cells by activating c-Src.
pubmed:affiliation
Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural