Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-12-10
pubmed:abstractText
Modular control analysis (MoCA; Diolez P, Deschodt-Arsac V, Raffard G, Simon C, Santos PD, Thiaudiere E, Arsac L, Franconi JM. Am J Physiol Regul Integr Comp Physiol 293: R13-R19, 2007) was applied here on perfused hearts to describe the modifications of the regulation of heart energetics induced in mice exposed to 3-wk chronic hypoxia. MoCA combines 31P-NMR spectroscopy and modular (top down) control analysis to describe the integrative regulation of energy metabolism in the intact beating heart, on the basis of two modules [ATP/phosphocreatine (PCr) production and ATP/PCr consumption] connected by the energetic intermediates. In contrast with previous results in rat heart, in which all control of contraction was on ATP demand, mouse heart energetics presented a shared control of contraction between ATP/PCr-producing and -consuming modules. In chronic hypoxic mice, the decrease in heart contractile activity and PCr-to-ATP ratio was surprisingly associated with an important and significant higher response of ATP/PCr production (elasticity) to PCr changes compared with control hearts (-10.4 vs. -2.46). By contrast, no changes were observed in ATP/PCr consumption since comparable elasticities were observed. Since elasticities determine the regulation of energetics of heart contraction, the present results show that this new parameter may be used to uncover the origin of the observed dysfunctions under chronic hypoxia conditions. Considering the decrease in mitochondrial content reported after exposure to chronic hypoxia, it appears that the improvement of ATP/PCr production response to ATP demand may be viewed as a positive adaptative mechanism. It now appears crucial to understand the very processes responsible for ATP/PCr producer elasticity toward the energetic intermediates, as well as their regulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0363-6119
pubmed:author
pubmed:issnType
Print
pubmed:volume
295
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R1891-7
pubmed:meshHeading
pubmed-meshheading:18832083-Adaptation, Physiological, pubmed-meshheading:18832083-Adenosine Triphosphate, pubmed-meshheading:18832083-Animals, pubmed-meshheading:18832083-Anoxia, pubmed-meshheading:18832083-Chronic Disease, pubmed-meshheading:18832083-Disease Models, Animal, pubmed-meshheading:18832083-Elasticity, pubmed-meshheading:18832083-Energy Metabolism, pubmed-meshheading:18832083-Female, pubmed-meshheading:18832083-Heart Rate, pubmed-meshheading:18832083-Kinetics, pubmed-meshheading:18832083-Magnetic Resonance Spectroscopy, pubmed-meshheading:18832083-Mice, pubmed-meshheading:18832083-Mitochondria, Heart, pubmed-meshheading:18832083-Myocardial Contraction, pubmed-meshheading:18832083-Myocardium, pubmed-meshheading:18832083-Phosphocreatine, pubmed-meshheading:18832083-Systems Biology, pubmed-meshheading:18832083-Ventricular Pressure
pubmed:year
2008
pubmed:articleTitle
Modular control analysis of effects of chronic hypoxia on mouse heart.
pubmed:affiliation
Résonance Magnétique des Systèmes Biologiques, UMR5536 Centre National de la Recherche Scientifique, Université Victor Segalen Bordeaux 2, 146 rue Léo-Saignat, 33076 Bordeaux cedex, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't