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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-2-19
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pubmed:abstractText |
The persistence of minimal residual disease (MRD) following therapy is an established prognostic factor in precursor B-cell acute lymphoblastic leukemia (pB-ALL). Detection of MRD in pB-ALL by flow cytometric immunophenotyping requires demonstration of abnormal antigen expression in leukemic B-cell precursors relative to that of normal B-cell precursors. The gene encoding CD49f (integrin alpha-6) is one of several whose overexpression in pB-ALL at diagnosis has been associated with the subsequent detection of MRD. However, whether CD49f might be a useful reagent in the immunophenotypic detection of MRD in pB-ALL has not been evaluated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1552-4957
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pubmed:author |
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pubmed:copyrightInfo |
2008 Clinical Cytometry Society.
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pubmed:issnType |
Electronic
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
150-5
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pubmed:dateRevised |
2009-12-11
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pubmed:meshHeading |
pubmed-meshheading:18831072-Adolescent,
pubmed-meshheading:18831072-Age Factors,
pubmed-meshheading:18831072-B-Lymphocytes,
pubmed-meshheading:18831072-Biological Markers,
pubmed-meshheading:18831072-Child,
pubmed-meshheading:18831072-Child, Preschool,
pubmed-meshheading:18831072-Female,
pubmed-meshheading:18831072-Flow Cytometry,
pubmed-meshheading:18831072-Humans,
pubmed-meshheading:18831072-Immunophenotyping,
pubmed-meshheading:18831072-Infant,
pubmed-meshheading:18831072-Integrin alpha6,
pubmed-meshheading:18831072-Male,
pubmed-meshheading:18831072-Neoplasm, Residual,
pubmed-meshheading:18831072-Neoplasm Recurrence, Local,
pubmed-meshheading:18831072-Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:18831072-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:18831072-Precursor Cells, B-Lymphoid,
pubmed-meshheading:18831072-Predictive Value of Tests,
pubmed-meshheading:18831072-Prognosis,
pubmed-meshheading:18831072-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Overexpression of CD49f in precursor B-cell acute lymphoblastic leukemia: potential usefulness in minimal residual disease detection.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, Hartford Hospital, Connecticut 06102-5037, USA. jdigius@harthosp.org
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pubmed:publicationType |
Journal Article
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