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pubmed-article:18829510pubmed:abstractTextEvidence has accumulated in recent years suggestive of a genetic basis for a susceptibility to the development of radiation injury after cancer radiotherapy. The purpose of this study was to assess whether patients with severe radiation-induced sequelae (RIS; i.e., National Cancer Institute/CTCv3.0 grade, > or =3) display both a low capacity of radiation-induced CD8 lymphocyte apoptosis (RILA) in vitro and possess certain single nucleotide polymorphisms (SNP) located in candidate genes associated with the response of cells to radiation.lld:pubmed
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pubmed-article:18829510pubmed:articleTitleSingle nucleotide polymorphisms, apoptosis, and the development of severe late adverse effects after radiotherapy.lld:pubmed
pubmed-article:18829510pubmed:affiliationINSERM U896, Institut de Recherche en Cancérologie de Montpellier, Department of Radiation Oncology, CRLC Val d'Aurelle-Paul Lamarque, Montpellier, France.lld:pubmed
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