Source:http://linkedlifedata.com/resource/pubmed/id/18824251
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2008-12-1
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| pubmed:abstractText |
We followed-up for mortality and cancer incidence 1088 healthy non-smokers from a population-based study, who were characterized for 22 variants in 16 genes involved in DNA repair pathways. Follow-up was 100% complete. The association between polymorphism and mortality or cancer incidence was analyzed using Cox Proportional Hazard regression models. Ninety-five subjects had died in a median follow-up time of 78 months (inter-quartile range 59-93 months). None of the genotypes was clearly associated with total mortality, except variants for two Double-Strand Break DNA repair genes, XRCC3 18067 C>T (rs#861539) and XRCC2 31479 G>A (rs#3218536). Adjusted hazard ratios were 2.25 (1.32-3.83) for the XRCC3 C/T genotype and 2.04 (1.00-4.13) for the T/T genotype (reference C/C), and 2.12 (1.14-3.97) for the XRCC2 G/A genotype (reference G/G). For total cancer mortality, the adjusted hazard ratios were 3.29 (1.23-7.82) for XRCC3 C/T, 2.84 (0.81-9.90) for XRCC3 T/T and 3.17 (1.21-8.30) for XRCC2 G/A. With combinations of three or more adverse alleles, the adjusted hazard ratio for all cause mortality was 17.29 (95% C.I. 8.13-36.74), and for all incident cancers the HR was 5.28 (95% C.I. 2.17-12.85). Observations from this prospective study suggest that polymorphisms of genes involved in the repair of DNA double-strand breaks significantly influence the risk of cancer and non-cancer disease, and can influence mortality.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
|
| pubmed:issn |
1568-7864
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| pubmed:author |
pubmed-author:BarricarteAurelioA,
pubmed-author:BenetouVassilikiV,
pubmed-author:BerglundGoranG,
pubmed-author:BinghamSheilaS,
pubmed-author:BoeingHeinerH,
pubmed-author:Bueno-De-MesquitaH BasHB,
pubmed-author:Clavel-ChapelonFrancoiseF,
pubmed-author:CrosignaniPaoloP,
pubmed-author:DiazTormo M JoseTM,
pubmed-author:DorronsoroMirenM,
pubmed-author:DunningAlisonA,
pubmed-author:FerrariPietroP,
pubmed-author:GalloValentinaV,
pubmed-author:GonzalezCarlos ACA,
pubmed-author:GuarreraSimonettaS,
pubmed-author:JarvholmBengtB,
pubmed-author:KeyTimothy JTJ,
pubmed-author:KhawKay TeeKT,
pubmed-author:LinseisenJakob PJP,
pubmed-author:LundEilivE,
pubmed-author:MalaveilleChristianC,
pubmed-author:MartinezCarmenC,
pubmed-author:MatulloGiuseppeG,
pubmed-author:NavarroCarmenC,
pubmed-author:NeashamDavidD,
pubmed-author:OvervadKimK,
pubmed-author:PalliDomenicoD,
pubmed-author:PanicoSalvatoreS,
pubmed-author:PeetersPetra HPH,
pubmed-author:QuirosJosè RJR,
pubmed-author:RiboliElioE,
pubmed-author:TjonnelandAnneA,
pubmed-author:TrichopoulouAntoniaA,
pubmed-author:TuminoRosarioR,
pubmed-author:VineisPaoloP,
pubmed-author:van GibCarla HCH
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| pubmed:issnType |
Print
|
| pubmed:day |
1
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| pubmed:volume |
8
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
60-71
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| pubmed:meshHeading |
pubmed-meshheading:18824251-Cohort Studies,
pubmed-meshheading:18824251-DNA Breaks, Double-Stranded,
pubmed-meshheading:18824251-DNA Repair,
pubmed-meshheading:18824251-Genetic Predisposition to Disease,
pubmed-meshheading:18824251-Genotype,
pubmed-meshheading:18824251-Humans,
pubmed-meshheading:18824251-Incidence,
pubmed-meshheading:18824251-Mortality,
pubmed-meshheading:18824251-Neoplasms,
pubmed-meshheading:18824251-Polymorphism, Genetic,
pubmed-meshheading:18824251-Prospective Studies,
pubmed-meshheading:18824251-Risk Factors
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| pubmed:year |
2009
|
| pubmed:articleTitle |
Double-strand break DNA repair genotype predictive of later mortality and cancer incidence in a cohort of non-smokers.
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| pubmed:affiliation |
Division of Epidemiology, Public Health & Primary Care, Imperial College, UK. david.neasham@googlemail.com
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|