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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2008-10-21
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pubmed:databankReference |
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pubmed:abstractText |
T helper type 2 (T(H)2) cells are essential for humoral immunity and host defense. Interleukin 4 (IL-4) drives T(H)2 differentiation and IL-2 augments the accessibility of Il4 chromatin. Here we demonstrate that IL-2, by inducing binding of STAT5 to the Il4ra locus, which encodes IL-4 receptor alpha-chain (IL-4Ralpha), was essential for inducing and maintaining IL-4Ralpha expression. Although IL-4 induced IL-4Ralpha expression, T cell receptor-induced IL-4Ralpha expression was normal in Il4(-/-) cells but was much lower in Il2(-/-) cells. Notably, forced IL-4Ralpha expression restored the T(H)2 differentiation of Il2(-/-) cells. Moreover, genome-wide mapping by chromatin immunoprecipitation coupled with sequencing showed broad interaction of the transcription factors STAT5A and STAT5B with genes associated with T(H)2 differentiation. Our results identify a previously unappreciated function for IL-2 in 'priming' T cells for T(H)2 differentiation and in maintaining the expression of Il4ra and other genes in T(H)2-committed cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-10358772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-10359822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-10594041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-10802665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-11290598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-11390477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-11485747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-12021241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-12049724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-12354940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-12461566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-12496402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-12500979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-12615888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-12835478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-1450403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-14614860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-15004274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-15340066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-15980098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-16551261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-16702603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-16911870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-17201677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-17512414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-17540862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-2016538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-3263373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-3263648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-7719938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-8552669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-8602264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-8624821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-8910586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-9053437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-9160750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-9380721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-9597132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18820682-9635196
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1529-2916
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1288-96
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pubmed:dateRevised |
2011-9-28
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pubmed:meshHeading |
pubmed-meshheading:18820682-Animals,
pubmed-meshheading:18820682-Cell Differentiation,
pubmed-meshheading:18820682-Gene Expression Regulation,
pubmed-meshheading:18820682-Interleukin-2,
pubmed-meshheading:18820682-Interleukin-4 Receptor alpha Subunit,
pubmed-meshheading:18820682-Mice,
pubmed-meshheading:18820682-Mice, Inbred C57BL,
pubmed-meshheading:18820682-Mice, Transgenic,
pubmed-meshheading:18820682-STAT5 Transcription Factor,
pubmed-meshheading:18820682-Th2 Cells,
pubmed-meshheading:18820682-Up-Regulation
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pubmed:year |
2008
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pubmed:articleTitle |
Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression.
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pubmed:affiliation |
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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