Linked Life Data

1881027

Source:http://linkedlifedata.com/resource/pubmed/id/1881027

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-10-3
pubmed:abstractText
The influence of tumor cell density on the antitumor effect of doxorubicin (DXR) in combination with cisplatin (CDDP) was studied in vitro using DND-39A lymphoma cells. DXR was progressively less effective on colony formation inhibition when cell density was increased from 10(5) to 10(8) viable cells/ml (positive inoculum effect), whereas the effect of CDDP was not influenced by cell densities. At a density of 10(5) cells/ml, inhibition of colony formation was virtually identical irrespective of cells being exposed to DXR and CDDP either simultaneously or sequentially. When cell density was increased to 10(7) and 10(8) cells/ml, sequential exposure to CDDP followed by DXR was more active than simultaneous or reversed order of exposure to the two drugs. These results indicate that for DXR-CDDP combination chemotherapy against the cells at high density, the proper sequence of the treatment should be the administration of CDDP followed by DXR, rather than simultaneous or reversed order of exposure. Inoculum effect may be an additional determinant for the rational development of combination chemotherapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-9717
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
78-81
pubmed:dateRevised
2008-8-7
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Antitumor efficacy of doxorubicin in combination with cisplatin on human lymphoma cells at various cell densities in vitro.
pubmed:affiliation
Department of Laboratory Medicine, National Defense Medical College, Saitama, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't