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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-12-16
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pubmed:abstractText |
In addition to genetic alterations, epigenetic changes underlie tumor progression and metastasis. Promoter methylation can silence tumor suppressor genes, and reactive oxygen species (ROS) promote DNA damage, although the relationship between ROS and epigenetic changes in cancer cells is not clear. We sought to determine whether ROS promote hypermethylation of the promoter region of E-cadherin, a regulator of the epithelial-to-mesenchymal transition, in hepatocellular carcinoma (HCC) cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
135
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2128-40, 2140.e1-8
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pubmed:meshHeading |
pubmed-meshheading:18801366-Adult,
pubmed-meshheading:18801366-Aged,
pubmed-meshheading:18801366-Cadherins,
pubmed-meshheading:18801366-Carcinoma, Hepatocellular,
pubmed-meshheading:18801366-Chromatin Immunoprecipitation,
pubmed-meshheading:18801366-DNA, Neoplasm,
pubmed-meshheading:18801366-Female,
pubmed-meshheading:18801366-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18801366-Humans,
pubmed-meshheading:18801366-Liver Neoplasms,
pubmed-meshheading:18801366-Male,
pubmed-meshheading:18801366-Methylation,
pubmed-meshheading:18801366-Middle Aged,
pubmed-meshheading:18801366-Polymerase Chain Reaction,
pubmed-meshheading:18801366-Promoter Regions, Genetic,
pubmed-meshheading:18801366-Reactive Oxygen Species,
pubmed-meshheading:18801366-Sequence Analysis, DNA,
pubmed-meshheading:18801366-Tumor Cells, Cultured
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pubmed:year |
2008
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pubmed:articleTitle |
Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter.
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pubmed:affiliation |
Department of Biological Sciences, Seoul National University, Seoul, Korea.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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