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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2008-9-26
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pubmed:abstractText |
As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that susceptibility alleles for ESRD have a higher frequency in the West African than the European gene pool. We carried out a genome-wide admixture scan in 1,372 ESRD cases and 806 controls and found a highly significant association between excess African ancestry and nondiabetic ESRD (lod score = 5.70) but not diabetic ESRD (lod = 0.47) on chromosome 22q12. Each copy of the European ancestral allele conferred a relative risk of 0.50 (95% CI = 0.39-0.63) compared to African ancestry. Multiple common SNPs (allele frequencies ranging from 0.2 to 0.6) in the gene encoding nonmuscle myosin heavy chain type II isoform A (MYH9) were associated with two to four times greater risk of nondiabetic ESRD and accounted for a large proportion of the excess risk of ESRD observed in African compared to European Americans.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/DK07024,
http://linkedlifedata.com/resource/pubmed/grant/HL62985,
http://linkedlifedata.com/resource/pubmed/grant/HS08365,
http://linkedlifedata.com/resource/pubmed/grant/K01DK067207,
http://linkedlifedata.com/resource/pubmed/grant/M01-RR-000080,
http://linkedlifedata.com/resource/pubmed/grant/M01-RR-00425,
http://linkedlifedata.com/resource/pubmed/grant/M01-RR-00827-29,
http://linkedlifedata.com/resource/pubmed/grant/M01-RR-01346,
http://linkedlifedata.com/resource/pubmed/grant/M01-RR-07122,
http://linkedlifedata.com/resource/pubmed/grant/N01-CO-12400,
http://linkedlifedata.com/resource/pubmed/grant/R01 DK059997-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 DK067528-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 DK072348-04,
http://linkedlifedata.com/resource/pubmed/grant/U01 DK070657-01,
http://linkedlifedata.com/resource/pubmed/grant/U01 DK070657-02,
http://linkedlifedata.com/resource/pubmed/grant/U01 DK070657-03,
http://linkedlifedata.com/resource/pubmed/grant/U01DK070657,
http://linkedlifedata.com/resource/pubmed/grant/U01DK57292,
http://linkedlifedata.com/resource/pubmed/grant/U01DK57304
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-10598801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-10973260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-11246470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-11904358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-11935325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-11943476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-12191981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-12435255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-15088269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-15088270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-15177524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-15339995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-15486828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-15642484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-15718463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-16012528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-16186815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-16453013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-16596254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-17401364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-17943122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-17975807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-18179887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-18818713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-19324247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-3194414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-7763126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-7942858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-8465818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-9109467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-9634509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18794854-9644638
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1546-1718
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pubmed:author |
pubmed-author:KaoW H LindaWH,
pubmed-author:CoreshJosefJ,
pubmed-author:PoweNeil RNR,
pubmed-author:FinkNancy ENE,
pubmed-author:SadlerJohn HJH,
pubmed-author:IyengarSudha KSK,
pubmed-author:AbboudHanna EHE,
pubmed-author:FreedmanBarry IBI,
pubmed-author:KnowlerWilliam CWC,
pubmed-author:ReichDavidD,
pubmed-author:SchellingJeffrey RJR,
pubmed-author:SedorJohn RJR,
pubmed-author:KlagMichael JMJ,
pubmed-author:NicholasSusanne BSB,
pubmed-author:WeirMatthew RMR,
pubmed-author:MeoniLucy ALA,
pubmed-author:KimmelPaul LPL,
pubmed-author:LeeheyDavid JDJ,
pubmed-author:AdlerSharon GSG,
pubmed-author:WinklerCheryl ACA,
pubmed-author:SmithMichael WMW,
pubmed-author:LiManM,
pubmed-author:PahlMadeleine VMV,
pubmed-author:PattersonNickN,
pubmed-author:Family Investigation of Nephropathy and Diabetes Research Group,
pubmed-author:KohnOrly FOF,
pubmed-author:ParekhRulan SRS,
pubmed-author:Berthier-SchaadYvetteY,
pubmed-author:TandonArtiA,
pubmed-author:Thornley-BrownDenyseD,
pubmed-author:DiversJasminJ
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