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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-2-16
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pubmed:abstractText |
ABO hemolytic disease of fetus and newborn (ABO-HDFN) occurs almost exclusively in infants of blood group A or B who are born to group O mothers because IgG anti-A or -B occurs more commonly in group O than in group A or B individuals. We report a case of clinically significant ABO-HDFN where the mother was blood group O with elevated IgG anti-A and anti-B titers and delivered a child with an A2B phenotype. This unusual ABO constellation between mother and infant was based on the inheritance of a rare ABO allele encoding for a glycosyltransferase capable of synthesizing both A and B antigens. Because both anti-A and anti-B antibodies may have been involved in hemolysis in this case, it may be relevant to consider the cisAB phenomenon when monitoring ABO-incompatible pregnancies and births.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
T
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1473-0502
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
123-8
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pubmed:meshHeading |
pubmed-meshheading:18793871-ABO Blood-Group System,
pubmed-meshheading:18793871-Adult,
pubmed-meshheading:18793871-Alleles,
pubmed-meshheading:18793871-Asian Continental Ancestry Group,
pubmed-meshheading:18793871-Blood Grouping and Crossmatching,
pubmed-meshheading:18793871-Erythroblastosis, Fetal,
pubmed-meshheading:18793871-Female,
pubmed-meshheading:18793871-Humans,
pubmed-meshheading:18793871-Immunoglobulin G,
pubmed-meshheading:18793871-Infant, Newborn,
pubmed-meshheading:18793871-Isoantibodies,
pubmed-meshheading:18793871-Isoantigens,
pubmed-meshheading:18793871-Jaundice, Neonatal,
pubmed-meshheading:18793871-Male,
pubmed-meshheading:18793871-Maternal-Fetal Exchange,
pubmed-meshheading:18793871-Oligosaccharides,
pubmed-meshheading:18793871-Parity,
pubmed-meshheading:18793871-Pedigree,
pubmed-meshheading:18793871-Phenotype,
pubmed-meshheading:18793871-Pregnancy,
pubmed-meshheading:18793871-Trisaccharides
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pubmed:year |
2008
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pubmed:articleTitle |
Haemolytic disease of fetus and newborn caused by ABO antibodies in a cisAB offspring.
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pubmed:affiliation |
ShenZhen Institute of Transfusion Medicine, ShenZhen Blood Center, ShenZhen, GuangDong, PR China. zhihui_deng@yahoo.com.com.cn
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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