Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-3-30
pubmed:abstractText
This study examines our hypothesis that translationally controlled tumor protein (TCTP) expression in CD4+ CD25(high) regulatory T cells (Tregs) is critical for the interleukin-2 (IL-2) withdrawal-triggered apoptosis pathway in Tregs, and modulation of Treg apoptosis pathway affects development of vascular inflammation. To test this hypothesis, we established a Tregs-specific TCTP antisense transgenic mouse model. Lower TCTP expression in Tregs than in CD4+ CD25- T cells is associated with the higher susceptibility of Tregs to apoptosis induced by IL-2 withdrawal. Overexpression of TCTP antisense in Tregs leads to decreased positive selection of CD25(high) thymic Tregs and reduced survival of peripheral Tregs, which is correlated to our previous report that TCTP antisense knocks-down TCTP protein expression and promotes apoptosis. In addition, TCTP antisense transgene confers higher susceptibility of Tregs to apoptosis induced by IL-2 withdrawal than wild-type Tregs, which can be suppressed by exogenous supply of IL-2, suggesting that IL-2 promotes Treg survival at least partially due to promoting TCTP expression. Finally, decreased expression of TCTP in Tregs aggravates experimental vascular inflammation, presumably due to increased Treg apoptosis and failure of decreased Tregs in suppressing inflammatory cells and immune cells. These results suggest that the modulation of Tregs apoptosis/survival may be used as a new therapeutic approach for inflammatory cardiovascular diseases.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-10428293, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-11298337, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-11812990, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-12093873, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-12106494, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-12244308, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-12506016, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-12719730, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-15036232, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-15307180, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-15322272, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-15343366, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-15466453, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-15514167, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-15583662, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-15784460, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-15827965, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-15870695, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-15902688, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-16020508, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-16285010, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-16462800, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-16829650, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-16903906, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-17154262, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-17183360, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-17272749, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-17277022, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-17346430, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-17954363, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-17981643, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-18304352, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-18508723, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-7489743, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-7738012, http://linkedlifedata.com/resource/pubmed/commentcorrection/18789801-9390687
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1879-1484
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
203
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
401-8
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Expression of TCTP antisense in CD25(high) regulatory T cells aggravates cuff-injured vascular inflammation.
pubmed:affiliation
Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, United States.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural