Source:http://linkedlifedata.com/resource/pubmed/id/18774954
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2008-11-21
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| pubmed:abstractText |
The transformation of follicular lymphoma (FL) to high-grade histology occurs in up to 70% of patients. The role of hematopoietic stem cell transplantation (HSCT) in transformed FL is poorly defined. Twenty-four FL patients with histologically confirmed transformation to diffuse large B-cell lymphoma underwent unpurged autologous HSCT at our institution. Their median age was 56 yr. The median number of prior chemotherapies was 2 (range 1-6). Thirteen patients had residual nodal disease measuring more than 2 cm and four patients had bulky disease at the time of HSCT. Six patients had refractory disease at transplantation. At a median follow-up of 38 months, 3-yr progression-free survival following autologous HSCT was 40%. The 3-yr overall survival was 52%. The cumulative incidence of relapse and non-relapse mortality rate was 41% and 25%, respectively.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1600-0609
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
81
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
425-31
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:18774954-Aged,
pubmed-meshheading:18774954-Antibodies, Monoclonal,
pubmed-meshheading:18774954-Antibodies, Monoclonal, Murine-Derived,
pubmed-meshheading:18774954-Antineoplastic Agents,
pubmed-meshheading:18774954-Disease-Free Survival,
pubmed-meshheading:18774954-Female,
pubmed-meshheading:18774954-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:18774954-Humans,
pubmed-meshheading:18774954-Lymphoma, Follicular,
pubmed-meshheading:18774954-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:18774954-Male,
pubmed-meshheading:18774954-Middle Aged,
pubmed-meshheading:18774954-Retrospective Studies,
pubmed-meshheading:18774954-Salvage Therapy,
pubmed-meshheading:18774954-Survival Rate,
pubmed-meshheading:18774954-Transplantation, Autologous,
pubmed-meshheading:18774954-Transplantation Conditioning
|
| pubmed:year |
2008
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| pubmed:articleTitle |
High-dose therapy and autologous stem cell transplantation for follicular lymphoma undergoing transformation to diffuse large B-cell lymphoma.
|
| pubmed:affiliation |
Department of Internal Medicine, Division of Hematology-Oncology, Arthur G James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA. mehdi.hamadani@gmail.com
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| pubmed:publicationType |
Journal Article
|