Source:http://linkedlifedata.com/resource/pubmed/id/18774539
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2008-9-8
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| pubmed:abstractText |
The physiopathogenesis of Alzheimer's disease (AD) is related to various biochemical mechanisms that may be reflected by changes in plasma components. In the current study, Fourier transform-infrared (FT-IR) spectroscopy was used to identify these biochemical variations by monitoring spectral differences in the plasma of 40 AD patients compared with those of 112 control subjects. A hierarchical classification in the whole mid-infrared region allowed a clear separation between AD and controls (C) that was optimized by using a restricted spectral range (1480-1428 cm(-1)). Spectral changes confirmed vibration differences between AD and C mostly related to modified lipid and nucleic acid structures involved in oxidative stress-dependent processes of AD. Moreover, the analysis of samples in the 1480-910-cm(-1) region allowed the distinction between C and AD with an accuracy of 98.4% and showed 2 subgroups C(1) and C(2) within the C group. Interestingly, the C(1) subgroup was located closer to the AD group than the C(2) subgroup, which suggests biochemical differences within the nondemented subjects. Biochemical studies revealed a significant increase in a specific marker of oxidative stress, F8-isoprostanes (8-epi-PGF2alpha) levels, in the plasma of AD patients as compared with total controls and subgroup C(2) but not subgroup C(1). Thus, these results suggest that use of FT-IR spectroscopy could be valuable to distinguish AD patients from normal-aging subjects.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
1931-5244
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
152
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
103-12
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| pubmed:meshHeading |
pubmed-meshheading:18774539-Aged,
pubmed-meshheading:18774539-Aging,
pubmed-meshheading:18774539-Alzheimer Disease,
pubmed-meshheading:18774539-Biological Markers,
pubmed-meshheading:18774539-Brief Psychiatric Rating Scale,
pubmed-meshheading:18774539-Cognition Disorders,
pubmed-meshheading:18774539-Diagnosis, Differential,
pubmed-meshheading:18774539-Early Diagnosis,
pubmed-meshheading:18774539-Female,
pubmed-meshheading:18774539-Humans,
pubmed-meshheading:18774539-Magnetic Resonance Imaging,
pubmed-meshheading:18774539-Male,
pubmed-meshheading:18774539-Neuropsychological Tests,
pubmed-meshheading:18774539-Oxidative Stress,
pubmed-meshheading:18774539-Predictive Value of Tests,
pubmed-meshheading:18774539-Reference Values,
pubmed-meshheading:18774539-Reproducibility of Results,
pubmed-meshheading:18774539-Spectrophotometry, Infrared
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| pubmed:year |
2008
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| pubmed:articleTitle |
Infrared spectroscopy: a reagent-free method to distinguish Alzheimer's disease patients from normal-aging subjects.
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| pubmed:affiliation |
INSERM U876, Université Bordeaux, France. evelyne.peuchant@biomemohv.u-bordeaux2.fr
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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