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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
44
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pubmed:dateCreated |
2008-10-27
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pubmed:abstractText |
A wide variety of peptidases associate with vital biological pathways, but the origin and evolution of their tremendous diversity are poorly defined. Application of the MEROPS classification to a comprehensive set of genomes yields a simple pattern of peptidase distribution and provides insight into the organization of proteolysis in all forms of life. Unexpectedly, a near ubiquitous core set of peptidases is shown to contain more types than those unique to higher multicellular organisms. From this core group, an array of eukaryote-specific peptidases evolved to yield well known intracellular and extracellular processes. The paucity of peptidase families unique to higher metazoa suggests gains in proteolytic network complexity required a limited number of biochemical inventions. These findings provide a framework for deeper investigation into the evolutionary forces that shaped each peptidase family and a roadmap to develop a timeline for their expansion as an interconnected system.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
283
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
30010-4
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pubmed:dateRevised |
2010-9-21
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pubmed:meshHeading |
pubmed-meshheading:18768474-Databases, Protein,
pubmed-meshheading:18768474-Evolution, Molecular,
pubmed-meshheading:18768474-Genome,
pubmed-meshheading:18768474-Genome, Archaeal,
pubmed-meshheading:18768474-Genome, Bacterial,
pubmed-meshheading:18768474-Humans,
pubmed-meshheading:18768474-Hydrolases,
pubmed-meshheading:18768474-Peptide Hydrolases,
pubmed-meshheading:18768474-Proteins,
pubmed-meshheading:18768474-Sequence Analysis, Protein,
pubmed-meshheading:18768474-Species Specificity,
pubmed-meshheading:18768474-Trypsin
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pubmed:year |
2008
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pubmed:articleTitle |
Evolution of peptidase diversity.
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pubmed:affiliation |
Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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