Source:http://linkedlifedata.com/resource/pubmed/id/18759767
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2008-11-6
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| pubmed:abstractText |
To meet growing demand for oral anticoagulation worldwide there has been increased dependence on computer-assistance in dosage although the safety and effectiveness of any of the individual computer-assisted dosage programs has not previously been established. This randomised multicentre clinical end-point study assessed a new version of the PARMA 5 program. It compared PARMA 5 safety and effectiveness with manual dosage by experienced medical staff at 19 centres with a known interest in oral anticoagulation. Target recruitment was 8000 patient-years, randomised to medical staff or PARMA-5 assisted dosage. Safety and effectiveness of the PARMA 5 program was compared with manual dosage. A total of 10,421 patients were recruited (15,369 patient-years) in the 5-year study. International normalised ratio (INR) tests numbered 167,791 with manual and 160,078 with PARMA 5 dosage. With parma 5 there was overall a non-significant reduction in clinical events but in the 2542 patients with deep vein thrombosis/pulmonary embolism, clinical events were significantly reduced (P = 0.005). Success in achieving 'time in target INR range' was also significantly greater with PARMA 5 compared with the dosage by experienced medical staff. This study demonstrated the safety and effectiveness of PARMA 5-assisted dosage.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1365-2141
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| pubmed:author |
pubmed-author:IbrahimSaiedS,
pubmed-author:JespersenJørgenJ,
pubmed-author:KeownMichelleM,
pubmed-author:LoweGordonG,
pubmed-author:MoiaMarcoM,
pubmed-author:PalaretiGualtieroG,
pubmed-author:PollerLeonL,
pubmed-author:RobertsChristopherC,
pubmed-author:TripodiArmandoA,
pubmed-author:TurpieAlexander GAG,
pubmed-author:van den BesselaarAton M H PAM,
pubmed-author:van der MeerFelix J MFJ
|
| pubmed:issnType |
Electronic
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| pubmed:volume |
143
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
274-83
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| pubmed:meshHeading |
pubmed-meshheading:18759767-Acenocoumarol,
pubmed-meshheading:18759767-Administration, Oral,
pubmed-meshheading:18759767-Adult,
pubmed-meshheading:18759767-Aged,
pubmed-meshheading:18759767-Aged, 80 and over,
pubmed-meshheading:18759767-Algorithms,
pubmed-meshheading:18759767-Anticoagulants,
pubmed-meshheading:18759767-Drug Therapy, Computer-Assisted,
pubmed-meshheading:18759767-Female,
pubmed-meshheading:18759767-Follow-Up Studies,
pubmed-meshheading:18759767-Humans,
pubmed-meshheading:18759767-International Normalized Ratio,
pubmed-meshheading:18759767-Male,
pubmed-meshheading:18759767-Middle Aged,
pubmed-meshheading:18759767-Phenprocoumon,
pubmed-meshheading:18759767-Pulmonary Embolism,
pubmed-meshheading:18759767-Software,
pubmed-meshheading:18759767-Software Design,
pubmed-meshheading:18759767-Treatment Outcome,
pubmed-meshheading:18759767-Venous Thrombosis,
pubmed-meshheading:18759767-Warfarin
|
| pubmed:year |
2008
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| pubmed:articleTitle |
A multicentre randomised clinical endpoint study of PARMA 5 computer-assisted oral anticoagulant dosage.
|
| pubmed:affiliation |
EAA Central Facility, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, UK. leon.poller@manchester.ac.uk
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| pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|