Linked Life Data

18753966

Source:http://linkedlifedata.com/resource/pubmed/id/18753966

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-9-22
pubmed:abstractText
High-grade neuroendocrine carcinomas (NECs) of the uterine corpus and ovary are very rare tumors, and whenever diagnosed, they are usually associated with epithelial carcinoma. Because of their rarity, the molecular characteristics of these tumors are still unknown. To shed some light, we studied the genetic abnormalities of each of the 2 components, NEC and adenocarcinoma, in 4 cases arising in the ovary and the uterine corpus using array-comparative genomic hybridization. Both components of all 4 cases showed almost similar genetic abnormalities. Genetic alterations exclusively seen in adenocarcinomas included losses of 2p21.1, 10q, 12q, 9p23, gains on 2p, 3p, 3q, 4p, 5q, 6q, 10p, 15q, and amplification of 6q22.31. However, the NEC component showed numerous additional genetic abnormalities in comparison with the adenocarcinomas including gain on 6p25.3-p21.2 and 19q12 and losses on 6q24.2-q27, 19q13.11-13.2, and 19q13.31-13.41, where numerous genes involved in the pathogenesis of epithelial ovarian carcinoma have been previously identified. Our data indicate that NEC and adenocarcinomas are, in most part, genetically similar tumors and might indeed have a common origin. However, the NEC components exhibited more genetic abnormalities in comparison with the adenocarcinoma, suggesting that when the NEC clones become more dedifferentiated, they acquire additional genetic abnormalities. Because of the limited cases analyzed, a larger study is still needed to confirm our observation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1538-7151
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
539-46
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Array-comparative genomic hybridization analysis of primary endometrial and ovarian high-grade neuroendocrine carcinoma associated with adenocarcinoma: mystery resolved?
pubmed:affiliation
Department of Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. pmhawech1@yahoo.com
pubmed:publicationType
Journal Article