|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1991-9-26
|
|
pubmed:abstractText |
Pre-S2 protein and its antibody were detected in 130 children with hepatitis B virus (HBV) infection and 30 with T6 hepatitis B (HB) vaccination. The results showed that pre-S2 was positive in most chronic persistent hepatitis (CPH) and chronic active hepatitis(CAH) patients, while anti-pre-S2 was positive in only 8% (2/92 cases) and 11.5% (3/26 cases) respectively. The positive rate of anti-pre-S2 was 78.9% (15/19 cases) in cases at the convalescent stage of acute hepatitis B, 91.7% (55/60 cases) in cases with T6 HB vaccination and 83.3% (25.30 cases) in naturally acquired anti-HBs children, while pre-S2 was not noted. Anti-pre-S2 was negatively related to ALT and positively to anti-HBs (P less than 0.01). The positive relation of pre-S2 to HBsAg was observed. These results suggest that pre-S2 could be a marker for HBV infection, and anti-pre-S2 may indicate a favourable prognosis of HBV infection. There was no correlation between anti-pre-S2 and pathogenic damages induced by HBV.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0366-6999
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
104
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
124-7
|
|
pubmed:dateRevised |
2004-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:1874011-Adolescent,
pubmed-meshheading:1874011-Antibodies, Viral,
pubmed-meshheading:1874011-Biological Markers,
pubmed-meshheading:1874011-Child,
pubmed-meshheading:1874011-Child, Preschool,
pubmed-meshheading:1874011-Female,
pubmed-meshheading:1874011-Hepatitis B,
pubmed-meshheading:1874011-Hepatitis B Surface Antigens,
pubmed-meshheading:1874011-Humans,
pubmed-meshheading:1874011-Infant,
pubmed-meshheading:1874011-Male,
pubmed-meshheading:1874011-Protein Precursors,
pubmed-meshheading:1874011-Viral Envelope Proteins
|
|
pubmed:year |
1991
|
|
pubmed:articleTitle |
Significance of pre-S2 protein and its antibody in children with HBV infections.
|
|
pubmed:affiliation |
302 Hospital of PLA, Beijing.
|
|
pubmed:publicationType |
Journal Article
|
