Linked Life Data

1873348

Source:http://linkedlifedata.com/resource/pubmed/id/1873348

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-9-25
pubmed:abstractText
Some peculiarities of ubiquinone (Q) biosynthesis in the livers of vitamin E-deficient rats induced in vitro by alpha-tocopherol and S-adenosylmethionine (SAM) were investigated. When [C3H3]SAM was used as a precursor, alpha-tocopherol added to the sample induced a marked elevation of the content of Q concomitantly with a drastic increase (2.82-fold) of specific radioactivity of Q in the liver as compared to control. Under identical conditions with 2-14C sodium acetate as precursor, exogenous alpha-tocopherol increased the content (by 31.4%) and specific radioactivity (by 65.2%) of Q in experimental samples, whereas the corresponding parameters of ubichromenol (QC) were essentially unchanged. SAM added to the incubation medium caused a marked increase in the content and specific radioactivity of both Q and QC as compared to control. Similar, and even more conspicuous changes were observed after combined administration of alpha-tocopherol and SAM. The role of vitamin E in the activation of methylation reactions at terminal steps of Q and QC biosynthesis in rat liver is discussed.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0320-9725
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
354-60
pubmed:dateRevised
2007-7-23
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
[The role of vitamin E in the biosynthesis of ubiquinone (Q) and ubichromenol (QC) in rat liver].
pubmed:publicationType
Journal Article, English Abstract