| pubmed-article:18728022 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18728022 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:18728022 | lifeskim:mentions | umls-concept:C0033325 | lld:lifeskim |
| pubmed-article:18728022 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:18728022 | lifeskim:mentions | umls-concept:C1292769 | lld:lifeskim |
| pubmed-article:18728022 | lifeskim:mentions | umls-concept:C0312738 | lld:lifeskim |
| pubmed-article:18728022 | lifeskim:mentions | umls-concept:C1261322 | lld:lifeskim |
| pubmed-article:18728022 | lifeskim:mentions | umls-concept:C1442161 | lld:lifeskim |
| pubmed-article:18728022 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:18728022 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:18728022 | pubmed:dateCreated | 2008-11-3 | lld:pubmed |
| pubmed-article:18728022 | pubmed:abstractText | In acute lymphoblastic leukemia, besides age and white cell count at diagnosis, the cytogenetic abnormalities t(9;22)/BCR-ABL and t(4;11)/MLL-AF4 are important prognostic markers and are often included in the treatment stratification of patients with adult acute lymphoblastic leukemia. Deletions in 9p are seen in about 9% of cases of adult acute lymphoblastic leukemia, but their prognostic impact has been controversial. Cytogenetic data from 381 patients diagnosed with B-precursor acute lymphoblastic leukemia were reviewed. Chromosomal analysis was successful in 240 cases. Of these cases, 18 (8%) had abnormalities in 9p and they were compared with patients with normal karyotypes and patients with t(9;22)/BCR-ABL. Patients with abnormalities of chromosome 9 showed significantly shorter overall survival compared with patients with normal karyotypes. In fact, overall survival was similar to that in the poor prognosis t(9;22)/BCR-ABL-positive group. Our data suggest that chromosomal abnormalities involving 9p may have a significant negative impact on survival in adult B-precursor acute lymphoblastic leukemia. | lld:pubmed |
| pubmed-article:18728022 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18728022 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18728022 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18728022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18728022 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18728022 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:18728022 | pubmed:issn | 1592-8721 | lld:pubmed |
| pubmed-article:18728022 | pubmed:author | pubmed-author:KarlssonKarin... | lld:pubmed |
| pubmed-article:18728022 | pubmed:author | pubmed-author:BernellPerP | lld:pubmed |
| pubmed-article:18728022 | pubmed:author | pubmed-author:HallböökHelen... | lld:pubmed |
| pubmed-article:18728022 | pubmed:author | pubmed-author:AhlgrenThomas... | lld:pubmed |
| pubmed-article:18728022 | pubmed:author | pubmed-author:LinderholmMat... | lld:pubmed |
| pubmed-article:18728022 | pubmed:author | pubmed-author:SmedmyrBengtB | lld:pubmed |
| pubmed-article:18728022 | pubmed:author | pubmed-author:HägglundHansH | lld:pubmed |
| pubmed-article:18728022 | pubmed:author | pubmed-author:AströmMariaM | lld:pubmed |
| pubmed-article:18728022 | pubmed:author | pubmed-author:LazarevicVlad... | lld:pubmed |
| pubmed-article:18728022 | pubmed:author | pubmed-author:HardlingMatsM | lld:pubmed |
| pubmed-article:18728022 | pubmed:author | pubmed-author:NahiHarethH | lld:pubmed |
| pubmed-article:18728022 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18728022 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:18728022 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18728022 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18728022 | pubmed:pagination | 1734-8 | lld:pubmed |
| pubmed-article:18728022 | pubmed:meshHeading | pubmed-meshheading:18728022... | lld:pubmed |
| pubmed-article:18728022 | pubmed:meshHeading | pubmed-meshheading:18728022... | lld:pubmed |
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| pubmed-article:18728022 | pubmed:meshHeading | pubmed-meshheading:18728022... | lld:pubmed |
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| pubmed-article:18728022 | pubmed:meshHeading | pubmed-meshheading:18728022... | lld:pubmed |
| pubmed-article:18728022 | pubmed:meshHeading | pubmed-meshheading:18728022... | lld:pubmed |
| pubmed-article:18728022 | pubmed:meshHeading | pubmed-meshheading:18728022... | lld:pubmed |
| pubmed-article:18728022 | pubmed:meshHeading | pubmed-meshheading:18728022... | lld:pubmed |
| pubmed-article:18728022 | pubmed:meshHeading | pubmed-meshheading:18728022... | lld:pubmed |
| pubmed-article:18728022 | pubmed:meshHeading | pubmed-meshheading:18728022... | lld:pubmed |
| pubmed-article:18728022 | pubmed:meshHeading | pubmed-meshheading:18728022... | lld:pubmed |
| pubmed-article:18728022 | pubmed:meshHeading | pubmed-meshheading:18728022... | lld:pubmed |
| pubmed-article:18728022 | pubmed:meshHeading | pubmed-meshheading:18728022... | lld:pubmed |
| pubmed-article:18728022 | pubmed:meshHeading | pubmed-meshheading:18728022... | lld:pubmed |
| pubmed-article:18728022 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18728022 | pubmed:articleTitle | An investigation into whether deletions in 9p reflect prognosis in adult precursor B-cell acute lymphoblastic leukemia: a multi-center study of 381 patients. | lld:pubmed |
| pubmed-article:18728022 | pubmed:affiliation | Haematology Centre, Karolinska University Hospital Huddinge,141 86 Stockholm, Sweden. hareth.nahi@karolinska.se | lld:pubmed |
| pubmed-article:18728022 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18728022 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18728022 | pubmed:publicationType | Multicenter Study | lld:pubmed |
