Source:http://linkedlifedata.com/resource/pubmed/id/18728022
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2008-11-3
|
| pubmed:abstractText |
In acute lymphoblastic leukemia, besides age and white cell count at diagnosis, the cytogenetic abnormalities t(9;22)/BCR-ABL and t(4;11)/MLL-AF4 are important prognostic markers and are often included in the treatment stratification of patients with adult acute lymphoblastic leukemia. Deletions in 9p are seen in about 9% of cases of adult acute lymphoblastic leukemia, but their prognostic impact has been controversial. Cytogenetic data from 381 patients diagnosed with B-precursor acute lymphoblastic leukemia were reviewed. Chromosomal analysis was successful in 240 cases. Of these cases, 18 (8%) had abnormalities in 9p and they were compared with patients with normal karyotypes and patients with t(9;22)/BCR-ABL. Patients with abnormalities of chromosome 9 showed significantly shorter overall survival compared with patients with normal karyotypes. In fact, overall survival was similar to that in the poor prognosis t(9;22)/BCR-ABL-positive group. Our data suggest that chromosomal abnormalities involving 9p may have a significant negative impact on survival in adult B-precursor acute lymphoblastic leukemia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1592-8721
|
| pubmed:author |
pubmed-author:AhlgrenThomasT,
pubmed-author:AströmMariaM,
pubmed-author:BernellPerP,
pubmed-author:HägglundHansH,
pubmed-author:HallböökHeleneH,
pubmed-author:HardlingMatsM,
pubmed-author:KarlssonKarinK,
pubmed-author:LazarevicVladimir LjVLj,
pubmed-author:LinderholmMatsM,
pubmed-author:NahiHarethH,
pubmed-author:SmedmyrBengtB
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
93
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1734-8
|
| pubmed:meshHeading |
pubmed-meshheading:18728022-Adolescent,
pubmed-meshheading:18728022-Adult,
pubmed-meshheading:18728022-Aged,
pubmed-meshheading:18728022-Burkitt Lymphoma,
pubmed-meshheading:18728022-Chromosome Mapping,
pubmed-meshheading:18728022-Chromosomes, Human, Pair 1,
pubmed-meshheading:18728022-Chromosomes, Human, Pair 22,
pubmed-meshheading:18728022-Chromosomes, Human, Pair 9,
pubmed-meshheading:18728022-Genetic Markers,
pubmed-meshheading:18728022-Humans,
pubmed-meshheading:18728022-Karyotyping,
pubmed-meshheading:18728022-Leukocyte Count,
pubmed-meshheading:18728022-Middle Aged,
pubmed-meshheading:18728022-Prognosis,
pubmed-meshheading:18728022-Sequence Deletion,
pubmed-meshheading:18728022-Survival Analysis,
pubmed-meshheading:18728022-Translocation, Genetic,
pubmed-meshheading:18728022-World Health Organization
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
An investigation into whether deletions in 9p reflect prognosis in adult precursor B-cell acute lymphoblastic leukemia: a multi-center study of 381 patients.
|
| pubmed:affiliation |
Haematology Centre, Karolinska University Hospital Huddinge,141 86 Stockholm, Sweden. hareth.nahi@karolinska.se
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|