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rdf:type |
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lifeskim:mentions |
umls-concept:C0005757,
umls-concept:C0009647,
umls-concept:C0012632,
umls-concept:C0034693,
umls-concept:C0220931,
umls-concept:C0348011,
umls-concept:C0871261,
umls-concept:C1272706,
umls-concept:C1704632,
umls-concept:C1705822,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
7
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pubmed:dateCreated |
2008-10-31
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pubmed:abstractText |
Eyeblink classical conditioning (EBC) was observed across a broad developmental period with tasks utilizing two interstimulus intervals (ISIs). In ISI discrimination, two distinct conditioned stimuli (CSs; light and tone) are reinforced with a periocular shock unconditioned stimulus (US) at two different CS-US intervals. Temporal uncertainty is identical in design with the exception that the same CS is presented at both intervals. Developmental changes in conditioning have been reported in each task beyond ages when single-ISI learning is well developed. The present study sought to replicate and extend these previous findings by testing each task at four separate ages. Consistent with previous findings, younger rats (postnatal day--PD23 and 30) trained in ISI discrimination showed evidence of enhanced cross-modal influence of the short CS-US pairing upon long CS conditioning relative to older subjects. ISI discrimination training at PD43-47 yielded outcomes similar to those in adults (PD65-71). Cross-modal transfer effects in this task therefore appear to diminish between PD30 and PD43-47. Comparisons of ISI discrimination with temporal uncertainty indicated that cross-modal transfer in ISI discrimination at the youngest ages did not represent complete generalization across CSs. ISI discrimination undergoes a more protracted developmental emergence than single-cue EBC and may be a more sensitive indicator of developmental disorders involving cerebellar dysfunction.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-10456058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-10456115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-10573566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-10594075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-10607361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-10689285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-10749076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-10832787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-10884335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-11160447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-11726236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-11805298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-12708525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-14509570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-14657256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-14674841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-1503658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-1503659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-15191638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-15897252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-16187829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-163116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-16741286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-17014257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-17324050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-17380527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-1744597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-1744598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-17680607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-18124807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-2002305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-2486500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-2706075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-2765164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-3057526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-3554242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-3580118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-3823305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-4075140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-4705237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-4866552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-5118253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-5721496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-7472484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-7925184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-8117241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-8463840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-8463846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-8786457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-9193148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-934721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-947479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-9704988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18726989-9705002
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1098-2302
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
647-64
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pubmed:dateRevised |
2010-9-21
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pubmed:meshHeading |
pubmed-meshheading:18726989-Age Factors,
pubmed-meshheading:18726989-Animals,
pubmed-meshheading:18726989-Visual Perception,
pubmed-meshheading:18726989-Rats,
pubmed-meshheading:18726989-Time Perception,
pubmed-meshheading:18726989-Auditory Perception,
pubmed-meshheading:18726989-Reaction Time,
pubmed-meshheading:18726989-Female,
pubmed-meshheading:18726989-Male,
pubmed-meshheading:18726989-Electroshock,
pubmed-meshheading:18726989-Discrimination Learning,
pubmed-meshheading:18726989-Conditioning, Eyelid
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