Linked Life Data

18718805

Source:http://linkedlifedata.com/resource/pubmed/id/18718805

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-4-20
pubmed:abstractText
We evaluated the neurological and neuropsychological profiles and olfaction as presymptomatic markers in a large family with Parkinson disease (PD) caused by the G2019S mutation in the LRRK2 gene. Five affected family members, 14 asymptomatic mutation carriers and 15 non-carriers were compared. Patients had typical dopa-responsive PD, frequently associated with cognitive impairment. Asymptomatic carriers and non-carriers could not be distinguished because of their neuropsychological status, the presence of depression or olfactory impairment. We were therefore unable to identify a presymptomatic marker of LRRK2-related PD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1873-5126
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
273-6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
A clinical, neuropsychological and olfactory evaluation of a large family with LRRK2 mutations.
pubmed:affiliation
INSERM, UMR_S679 Neurologie & Thérapeutique Expérimentale, F-75013 Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't