| pubmed-article:18715473 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18715473 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:18715473 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:18715473 | lifeskim:mentions | umls-concept:C0020649 | lld:lifeskim |
| pubmed-article:18715473 | lifeskim:mentions | umls-concept:C0020456 | lld:lifeskim |
| pubmed-article:18715473 | lifeskim:mentions | umls-concept:C0699748 | lld:lifeskim |
| pubmed-article:18715473 | lifeskim:mentions | umls-concept:C1441672 | lld:lifeskim |
| pubmed-article:18715473 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:18715473 | pubmed:dateCreated | 2008-8-21 | lld:pubmed |
| pubmed-article:18715473 | pubmed:abstractText | The role of hyperglycaemia in the pathogenesis of hypotension in diabetic disorders was investigated using the changes in cardiac M(2)-muscarinic receptor (M(2)-mAChR) gene expression in type-1-like diabetic rats and cultured cardiomyocytes. Blood pressure was markedly decreased in diabetic rats following the intravenous injection of streptozotocin (STZ) for 8 weeks. Also, the baroreflex sensitivity (Delta HR/Delta BP), as measured by the changes in heart rate (Delta HR) and mean blood pressure (Delta BP) 1 min after the intravenous injection of phenylephrine (10 microg/kg), was significantly increased. Arecaidine propargyl ester (APE), a M(2)-mAChR agonist produced a marked reduction in heart rate in these diabetic rats. Normalization of plasma glucose in diabetic rats using insulin (0.5 IU) or phlorizin (1 mg/kg) injection attenuated the blood pressure reduction and reversed the mRNA and protein levels of cardiac M(2)-mAChR. A high concentration of glucose (20 mmol/l) directly influenced the increase in gene expression of M(2)-mAChR in the H9c2 cardiac cell line. Hyperglycaemia induced an increase in cardiac M(2)-mAChR gene expression, suggesting a role in the pathogenesis of hypotension in diabetic disorders. | lld:pubmed |
| pubmed-article:18715473 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18715473 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18715473 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18715473 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18715473 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18715473 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18715473 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18715473 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18715473 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18715473 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18715473 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18715473 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18715473 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18715473 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18715473 | pubmed:issn | 1365-2613 | lld:pubmed |
| pubmed-article:18715473 | pubmed:author | pubmed-author:LiuI-MinIM | lld:pubmed |
| pubmed-article:18715473 | pubmed:author | pubmed-author:ChengJuei-Tan... | lld:pubmed |
| pubmed-article:18715473 | pubmed:author | pubmed-author:TongYat-Ching... | lld:pubmed |
| pubmed-article:18715473 | pubmed:author | pubmed-author:ChangCheng... | lld:pubmed |
| pubmed-article:18715473 | pubmed:author | pubmed-author:JuangShiow-We... | lld:pubmed |
| pubmed-article:18715473 | pubmed:author | pubmed-author:ChengKai-Chun... | lld:pubmed |
| pubmed-article:18715473 | pubmed:author | pubmed-author:KouDai-HuangD... | lld:pubmed |
| pubmed-article:18715473 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18715473 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:18715473 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18715473 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18715473 | pubmed:pagination | 292-300 | lld:pubmed |
| pubmed-article:18715473 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:18715473 | pubmed:meshHeading | pubmed-meshheading:18715473... | lld:pubmed |
| pubmed-article:18715473 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18715473 | pubmed:articleTitle | Role of hyperglycaemia in the pathogenesis of hypotension observed in type-1 diabetic rats. | lld:pubmed |
| pubmed-article:18715473 | pubmed:affiliation | Department of Pharmacy, Tajen University, Yen-Pou, Ping Tung Shien, Taiwan. | lld:pubmed |
| pubmed-article:18715473 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18715473 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
