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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-8-21
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pubmed:abstractText |
The role of hyperglycaemia in the pathogenesis of hypotension in diabetic disorders was investigated using the changes in cardiac M(2)-muscarinic receptor (M(2)-mAChR) gene expression in type-1-like diabetic rats and cultured cardiomyocytes. Blood pressure was markedly decreased in diabetic rats following the intravenous injection of streptozotocin (STZ) for 8 weeks. Also, the baroreflex sensitivity (Delta HR/Delta BP), as measured by the changes in heart rate (Delta HR) and mean blood pressure (Delta BP) 1 min after the intravenous injection of phenylephrine (10 microg/kg), was significantly increased. Arecaidine propargyl ester (APE), a M(2)-mAChR agonist produced a marked reduction in heart rate in these diabetic rats. Normalization of plasma glucose in diabetic rats using insulin (0.5 IU) or phlorizin (1 mg/kg) injection attenuated the blood pressure reduction and reversed the mRNA and protein levels of cardiac M(2)-mAChR. A high concentration of glucose (20 mmol/l) directly influenced the increase in gene expression of M(2)-mAChR in the H9c2 cardiac cell line. Hyperglycaemia induced an increase in cardiac M(2)-mAChR gene expression, suggesting a role in the pathogenesis of hypotension in diabetic disorders.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arecoline,
http://linkedlifedata.com/resource/pubmed/chemical/Cholinergic Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Phlorhizin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Muscarinic M2,
http://linkedlifedata.com/resource/pubmed/chemical/arecaidine
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1365-2613
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
292-300
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18715473-Animals,
pubmed-meshheading:18715473-Arecoline,
pubmed-meshheading:18715473-Baroreflex,
pubmed-meshheading:18715473-Cell Line,
pubmed-meshheading:18715473-Cholinergic Agonists,
pubmed-meshheading:18715473-Diabetes Mellitus, Experimental,
pubmed-meshheading:18715473-Diabetes Mellitus, Type 1,
pubmed-meshheading:18715473-Gene Expression,
pubmed-meshheading:18715473-Glucose,
pubmed-meshheading:18715473-Hyperglycemia,
pubmed-meshheading:18715473-Hypotension,
pubmed-meshheading:18715473-Insulin,
pubmed-meshheading:18715473-Male,
pubmed-meshheading:18715473-Phenylephrine,
pubmed-meshheading:18715473-Phlorhizin,
pubmed-meshheading:18715473-RNA, Messenger,
pubmed-meshheading:18715473-Rats,
pubmed-meshheading:18715473-Rats, Wistar,
pubmed-meshheading:18715473-Receptor, Muscarinic M2
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pubmed:year |
2008
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pubmed:articleTitle |
Role of hyperglycaemia in the pathogenesis of hypotension observed in type-1 diabetic rats.
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pubmed:affiliation |
Department of Pharmacy, Tajen University, Yen-Pou, Ping Tung Shien, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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