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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2008-8-18
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pubmed:abstractText |
Genome-wide association studies are discovering relationships between single-nucleotide polymorphisms and breast cancer, but the functions of these single-nucleotide polymorphisms are unknown and environmental exposures are likely to be important. We assessed whether breast cancer risk single-nucleotide polymorphisms interacted with ionizing radiation, a known breast carcinogen, among 859 cases and 1,083 controls nested in the U.S. Radiologic Technologists cohort. Among 11 Breast Cancer Association Consortium risk single-nucleotide polymorphisms, we found that the genotype-associated breast cancer risk varied significantly by radiation dose for rs2107425 in the H19 gene (P(interaction) = 0.001). H19 is a maternally expressed imprinted mRNA that is closely involved in regulating the IGF2 gene and could exert its influence by this or by some other radiation-related pathway.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18708391-11566611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18708391-12784345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18708391-12947391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18708391-15352122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18708391-15642178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18708391-16359639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18708391-16575179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18708391-16639729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18708391-16808606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18708391-17523852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18708391-17529967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18708391-17618282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18708391-17764108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18708391-17932347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18708391-2053936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18708391-3312274
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1055-9965
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pubmed:author |
pubmed-author:AbendMichaelM,
pubmed-author:AlexanderBruce HBH,
pubmed-author:BhattiParveenP,
pubmed-author:DoodyMichele MMM,
pubmed-author:PharoahPaulP,
pubmed-author:PrestonDale LDL,
pubmed-author:RosensteinMarvinM,
pubmed-author:SigurdsonAlice JAJ,
pubmed-author:SimonSteven LSL,
pubmed-author:StovallMarilynM,
pubmed-author:StruewingJeffery PJP,
pubmed-author:WeinstockRobert MRM,
pubmed-author:YuengerJeffJ
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2007-11
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18708391-Breast Neoplasms,
pubmed-meshheading:18708391-Case-Control Studies,
pubmed-meshheading:18708391-Chi-Square Distribution,
pubmed-meshheading:18708391-Female,
pubmed-meshheading:18708391-Genotype,
pubmed-meshheading:18708391-Humans,
pubmed-meshheading:18708391-Incidence,
pubmed-meshheading:18708391-Likelihood Functions,
pubmed-meshheading:18708391-Male,
pubmed-meshheading:18708391-Middle Aged,
pubmed-meshheading:18708391-Neoplasms, Radiation-Induced,
pubmed-meshheading:18708391-Occupational Exposure,
pubmed-meshheading:18708391-Polymorphism, Single Nucleotide,
pubmed-meshheading:18708391-Radiation, Ionizing,
pubmed-meshheading:18708391-United States
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pubmed:year |
2008
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pubmed:articleTitle |
Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists.
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pubmed:affiliation |
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892-7238, USA. bhattip@mail.NIH.gov
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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