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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-10-10
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pubmed:abstractText |
In the kidney, approximately 80% of the filtered phosphate (Pi) is reabsorbed along the proximal tubule. Changes in renal Pi reabsorption are associated with modulation of the sodium-dependent Pi cotransporter type IIa (NaPi-IIa) and type IIc (NaPi-IIc) protein abundance in the brush-border membrane (BBM) of proximal tubule cells. NaPi-IIa is mainly regulated by dietary Pi intake and parathyroid hormone (PTH). The purpose of the present study was to elucidate the effect of alteration in dietary magnesium (Mg2+) intake on renal Pi handling. Urinary Pi excretion and renal expression of NaPi-IIa and NaPi-IIc were analyzed in rats fed a normal (0.2%) or high-Mg2+ (2.5%) diet. A high-Mg2+ diet resulted in decreased renal Pi excretion and increased protein expression of NaPi-IIa and NaPi-IIc. Serum FGF-23 (fibroblast growth factor 23) levels were unchanged under a high-Mg2+ diet. Serum PTH levels were slightly decreased under a high-Mg2+ diet. To examine whether the observed changes in renal Pi reabsorption are PTH dependent, expression of NaPi-IIa and NaPi-IIc was also analyzed in parathyroidectomized (PTX) rats fed a normal or high-Mg2+ diet. In PTX rats, Mg2+ had no significant effect on renal Pi excretion or NaPi-IIa protein expression. Mg2+ increased NaPi-IIc protein expression in PTX rats. This experiment shows for the first time on the molecular level how Mg2+ stimulates renal Pi reabsorption. Under a high-Mg2+ diet, NaPi-IIa expression is dependent on PTH levels, whereas NaPi-IIc expression seems to be independent of PTH levels.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Fgf23 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Linoleic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Magnesium,
http://linkedlifedata.com/resource/pubmed/chemical/Parathyroid Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Slc34a1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/So 1100,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Phosphate Cotransporter...,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Phosphate Cotransporter...,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Linolenic Acid
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1931-857X
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pubmed:author |
pubmed-author:AmashehSalahS,
pubmed-author:BiberJürgJ,
pubmed-author:JungSusanneS,
pubmed-author:KrämerStephanieS,
pubmed-author:MüllerDominikD,
pubmed-author:MeijIwanI,
pubmed-author:MurerHeiniH,
pubmed-author:PetersHarmH,
pubmed-author:QuerfeldUweU,
pubmed-author:SommerKerstinK,
pubmed-author:ThumfartJuliaJ,
pubmed-author:WagnerCarsten ACA
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pubmed:issnType |
Print
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pubmed:volume |
295
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
F1126-33
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pubmed:dateRevised |
2011-4-28
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pubmed:meshHeading |
pubmed-meshheading:18701629-Animal Feed,
pubmed-meshheading:18701629-Animals,
pubmed-meshheading:18701629-Fibroblast Growth Factors,
pubmed-meshheading:18701629-Immunohistochemistry,
pubmed-meshheading:18701629-Kidney,
pubmed-meshheading:18701629-Linoleic Acids,
pubmed-meshheading:18701629-Magnesium,
pubmed-meshheading:18701629-Male,
pubmed-meshheading:18701629-Parathyroid Hormone,
pubmed-meshheading:18701629-Parathyroidectomy,
pubmed-meshheading:18701629-Phosphates,
pubmed-meshheading:18701629-RNA, Messenger,
pubmed-meshheading:18701629-Rats,
pubmed-meshheading:18701629-Rats, Sprague-Dawley,
pubmed-meshheading:18701629-Sodium-Phosphate Cotransporter Proteins, Type IIa,
pubmed-meshheading:18701629-Sodium-Phosphate Cotransporter Proteins, Type IIc,
pubmed-meshheading:18701629-gamma-Linolenic Acid
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pubmed:year |
2008
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pubmed:articleTitle |
Magnesium stimulates renal phosphate reabsorption.
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pubmed:affiliation |
Department of Pediatric Nephrology, Charité University Children's Hospital, Augustenburger Platz 1, 13353 Berlin, Germany.
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pubmed:publicationType |
Journal Article
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