Linked Life Data

18698565

Source:http://linkedlifedata.com/resource/pubmed/id/18698565

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2008-10-6
pubmed:abstractText
Self-organization in mixed self-assembled monolayers of small molecules provides a route towards nanoparticles with complex molecular structures. Inspired by structural biology, a strategy based on chemical cross-linking is introduced to probe proximity between functional peptides embedded in a mixed self-assembled monolayer at the surface of a nanoparticle. The physical basis of the proximity measurement is a transition from intramolecular to intermolecular cross-linking as the functional peptides get closer. Experimental investigations of a binary peptide self-assembled monolayer show that this transition happens at an extremely low molar ratio of the functional versus matrix peptide. Molecular dynamics simulations of the peptide self-assembled monolayer are used to calculate the volume explored by the reactive groups. Comparison of the experimental results with a probabilistic model demonstrates that the peptides are not randomly distributed at the surface of the nanoparticle, but rather self-organize into supramolecular domains.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1439-7633
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2127-34
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Supramolecular domains in mixed peptide self-assembled monolayers on gold nanoparticles.
pubmed:affiliation
School of Biological Sciences and Liverpool Institute of Nanoscale Science, Engineering and Technology, University of Liverpool, Biosciences Building, Crown Street, Liverpool L697ZB, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't