Linked Life Data

18698151

Source:http://linkedlifedata.com/resource/pubmed/id/18698151

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-2-13
pubmed:abstractText
MicroRNA-mediated gene regulation allows the establishment of complex circuitries acting in many different phases of development and differentiation. MicroRNA genes and their target sites are under Darwinian selection and the idea that microRNAs can act as prime players in determining species identity has been recently speculated. By studying the 3'-untranslated regions (UTRs) of orthologous neuronal genes, we found that, at variance with house-keeping genes, the density of miRNA target sites involved in complex cell networks increased from invertebrates to human, paralleling the increase in species complexity. This suggests that genes contributing to complex cellular functions had a selective advantage for acquiring and potentiate miRNA-mediated regulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1555-8584
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
120-122
pubmed:dateRevised
2010-1-15
pubmed:meshHeading
pubmed:articleTitle
MicroRNAs as prime players in a combinatorial view of evolution.
pubmed:affiliation
Institute Pasteur Cenci-Bolognetti, Department of Genetics and Molecular Biology and I.B.P.M., University of Rome La Sapienza, Rome, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't