Source:http://linkedlifedata.com/resource/pubmed/id/18696274
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2009-2-4
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| pubmed:abstractText |
Psychotic symptoms are common in Alzheimer's disease (AD) and have a negative impact on quality of life. It is suggested that psychotic symptoms may be attributed to genetic risk factors which are revealed during neurodegeneration. CHRNA7, the gene for the alpha 7 nicotinic acetylcholine receptor, has been associated with schizophrenia in linkage and association studies. Hence we investigated single SNPs and haplotypes in CHRNA7 in relation to AD with psychosis in a large, well-characterised and previously described cohort within the Northern Ireland population. A significant association between delusions and the T allele of rs6494223 (P = 0.014, OR = 1.63, CI = 1.22-2.17) was found. This suggests that the alpha 7 receptor may be a suitable target for the treatment of AD with psychosis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1559-1174
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
10
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
377-84
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| pubmed:dateRevised |
2010-6-4
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| pubmed:meshHeading |
pubmed-meshheading:18696274-Acetylcholine,
pubmed-meshheading:18696274-Aged,
pubmed-meshheading:18696274-Aged, 80 and over,
pubmed-meshheading:18696274-Alzheimer Disease,
pubmed-meshheading:18696274-Brain Chemistry,
pubmed-meshheading:18696274-Cohort Studies,
pubmed-meshheading:18696274-DNA Mutational Analysis,
pubmed-meshheading:18696274-Female,
pubmed-meshheading:18696274-Gene Frequency,
pubmed-meshheading:18696274-Genetic Markers,
pubmed-meshheading:18696274-Genetic Predisposition to Disease,
pubmed-meshheading:18696274-Genetic Testing,
pubmed-meshheading:18696274-Genetic Variation,
pubmed-meshheading:18696274-Haplotypes,
pubmed-meshheading:18696274-Humans,
pubmed-meshheading:18696274-Male,
pubmed-meshheading:18696274-Middle Aged,
pubmed-meshheading:18696274-Polymorphism, Single Nucleotide,
pubmed-meshheading:18696274-Receptors, Nicotinic,
pubmed-meshheading:18696274-Schizophrenia, Paranoid,
pubmed-meshheading:18696274-Synaptic Transmission
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| pubmed:year |
2008
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| pubmed:articleTitle |
Genetic variation in the alpha 7 nicotinic acetylcholine receptor is associated with delusional symptoms in Alzheimer's disease.
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| pubmed:affiliation |
Division of Psychiatry and Neuroscience, School of Medicine and Dentistry, Queen's University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK. robyn.carson@qub.ac.uk
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| pubmed:publicationType |
Journal Article
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