| pubmed-article:18694728 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18694728 | lifeskim:mentions | umls-concept:C0052441 | lld:lifeskim |
| pubmed-article:18694728 | lifeskim:mentions | umls-concept:C1416433 | lld:lifeskim |
| pubmed-article:18694728 | lifeskim:mentions | umls-concept:C1564138 | lld:lifeskim |
| pubmed-article:18694728 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:18694728 | lifeskim:mentions | umls-concept:C1514762 | lld:lifeskim |
| pubmed-article:18694728 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:18694728 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:18694728 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:18694728 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18694728 | pubmed:dateCreated | 2008-9-11 | lld:pubmed |
| pubmed-article:18694728 | pubmed:abstractText | Aryl hydrocarbon receptor (AhR) activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to immune suppression associated with the induction of regulatory T cells (T(reg)) expressing the transcription factor Foxp3. The immunological mechanisms of suppression are not well understood however dendritic cells (DC) are considered a key target for AhR-mediated immune suppression. Here we show that activation of AhR by TCDD induces DC indoleamine 2,3-dioxygenase 1 (IDO1) and indoleamine 2,3-dioxygenase-like protein (IDO2). Induction of IDO1 and IDO2 was also found in lung and spleen associated with an increase of the T(reg) marker Foxp3 in spleen of TCDD-treated C57BL/6 mice, which is suppressed by inhibition of IDO. These data indicate that AhR-activation is an important signaling pathway for IDO expression and suggest a critical role of IDO in the mechanism leading to the generation of T(reg) that mediates the immune suppression through activation of AhR. | lld:pubmed |
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| pubmed-article:18694728 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18694728 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18694728 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18694728 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18694728 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:18694728 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:18694728 | pubmed:author | pubmed-author:MatsumuraFumi... | lld:pubmed |
| pubmed-article:18694728 | pubmed:author | pubmed-author:VogelChristop... | lld:pubmed |
| pubmed-article:18694728 | pubmed:author | pubmed-author:PessahIsaac... | lld:pubmed |
| pubmed-article:18694728 | pubmed:author | pubmed-author:DongBinB | lld:pubmed |
| pubmed-article:18694728 | pubmed:author | pubmed-author:GothSamuel... | lld:pubmed |
| pubmed-article:18694728 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18694728 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:18694728 | pubmed:volume | 375 | lld:pubmed |
| pubmed-article:18694728 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18694728 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18694728 | pubmed:pagination | 331-5 | lld:pubmed |
| pubmed-article:18694728 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:18694728 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18694728 | pubmed:articleTitle | Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase. | lld:pubmed |
| pubmed-article:18694728 | pubmed:affiliation | Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, CA 95616, USA. | lld:pubmed |
| pubmed-article:18694728 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18694728 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:18694728 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18694728 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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