|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2008-9-11
|
|
pubmed:abstractText |
Aryl hydrocarbon receptor (AhR) activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to immune suppression associated with the induction of regulatory T cells (T(reg)) expressing the transcription factor Foxp3. The immunological mechanisms of suppression are not well understood however dendritic cells (DC) are considered a key target for AhR-mediated immune suppression. Here we show that activation of AhR by TCDD induces DC indoleamine 2,3-dioxygenase 1 (IDO1) and indoleamine 2,3-dioxygenase-like protein (IDO2). Induction of IDO1 and IDO2 was also found in lung and spleen associated with an increase of the T(reg) marker Foxp3 in spleen of TCDD-treated C57BL/6 mice, which is suppressed by inhibition of IDO. These data indicate that AhR-activation is an important signaling pathway for IDO expression and suggest a critical role of IDO in the mechanism leading to the generation of T(reg) that mediates the immune suppression through activation of AhR.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18694728-11811931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18694728-12228717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18694728-15459668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18694728-15899923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18694728-16176799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18694728-16177056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18694728-17234791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18694728-17483297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18694728-17499941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18694728-17502624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18694728-17615586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18694728-17823304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18694728-17900530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18694728-18362914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18694728-18362915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18694728-3123485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18694728-9712583
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1090-2104
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
24
|
|
pubmed:volume |
375
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
331-5
|
|
pubmed:dateRevised |
2011-9-26
|
|
pubmed:meshHeading |
pubmed-meshheading:18694728-Animals,
pubmed-meshheading:18694728-Immune Tolerance,
pubmed-meshheading:18694728-Indoleamine-Pyrrole 2,3,-Dioxygenase,
pubmed-meshheading:18694728-Interferon-gamma,
pubmed-meshheading:18694728-Mice,
pubmed-meshheading:18694728-Mice, Inbred C57BL,
pubmed-meshheading:18694728-Receptors, Aryl Hydrocarbon,
pubmed-meshheading:18694728-Signal Transduction,
pubmed-meshheading:18694728-T-Lymphocytes, Regulatory,
pubmed-meshheading:18694728-Tetrachlorodibenzodioxin
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase.
|
|
pubmed:affiliation |
Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, CA 95616, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
