Source:http://linkedlifedata.com/resource/pubmed/id/18692411
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2008-10-22
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pubmed:abstractText |
Diagnosis of carotid body tumor (CBT) was made in a 36 years old woman. The pre-operative examination included genetic analysis of the succinate dehydrogenase that showed a mutation in his subunit D responsible of multiple paraganglioma at slow growth. Subsequently a thoraco-abdominal CT and indium(111) octreotide body scan were performed and another paraganglioma was detected in the anterior mediastinum. CBT was surgically removed; differently the thoracic lesion due to his benign genetic profile was not treated. During a 3-years follow-up the thoracic paraganglioma as expected, didn't increase. Genetic analysis of succinate dehydrogenase, should be performed in the management of CBT.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1532-2165
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
517-9
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pubmed:meshHeading |
pubmed-meshheading:18692411-Adult,
pubmed-meshheading:18692411-Cardiac Surgical Procedures,
pubmed-meshheading:18692411-Carotid Body Tumor,
pubmed-meshheading:18692411-DNA Mutational Analysis,
pubmed-meshheading:18692411-Female,
pubmed-meshheading:18692411-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:18692411-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18692411-Humans,
pubmed-meshheading:18692411-Magnetic Resonance Angiography,
pubmed-meshheading:18692411-Mediastinal Neoplasms,
pubmed-meshheading:18692411-Polymorphism, Single Nucleotide,
pubmed-meshheading:18692411-Succinate Dehydrogenase,
pubmed-meshheading:18692411-Syndrome,
pubmed-meshheading:18692411-Tomography, X-Ray Computed,
pubmed-meshheading:18692411-Treatment Outcome
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pubmed:year |
2008
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pubmed:articleTitle |
Role of the genetic study in the management of carotid body tumor in paraganglioma syndrome.
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pubmed:affiliation |
Department of Cardiac, Thoracic and Vascular Sciences, Section of Vascular and Endovascular Surgery, University of Padua, Italy. michele.antonello.1@unipd.it
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pubmed:publicationType |
Journal Article,
Case Reports
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