| pubmed-article:18689877 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18689877 | lifeskim:mentions | umls-concept:C1858460 | lld:lifeskim |
| pubmed-article:18689877 | lifeskim:mentions | umls-concept:C0013936 | lld:lifeskim |
| pubmed-article:18689877 | lifeskim:mentions | umls-concept:C0598175 | lld:lifeskim |
| pubmed-article:18689877 | lifeskim:mentions | umls-concept:C0031678 | lld:lifeskim |
| pubmed-article:18689877 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:18689877 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:18689877 | lifeskim:mentions | umls-concept:C1513354 | lld:lifeskim |
| pubmed-article:18689877 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:18689877 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:18689877 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:18689877 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:18689877 | pubmed:dateCreated | 2008-8-19 | lld:pubmed |
| pubmed-article:18689877 | pubmed:abstractText | Protein phosphatase-1 (PP1) is a major Ser/Thr phosphatase conserved among all eukaryotes, present as the essential GLC7 gene in yeast. Inhibitor-2 (I-2) is an ancient PP1 regulator, named GLC8 in yeast, but its in vivo function is unknown. Unlike mammals with multiple I-2 genes, in Drosophila there is a single I-2 gene, and here we describe its maternally derived expression and required function during embryogenesis. During oogenesis, germline expression of I-2 results in the accumulation of RNA and abundant protein in unfertilized eggs; in embryos, the endogenous I-2 protein concentrates around condensed chromosomes during mitosis and also surrounds interphase nuclei. An I-2 loss-of-function genotype is associated with a maternal-effect phenotype that results in drastically reduced progeny viability, as measured by reduced embryonic hatch rates and larval lethality. Embryos derived from I-2 mutant mothers show faulty chromosome segregation and loss of mitotic synchrony in cleavage-stage embryos, patchy loss of nuclei in syncytial blastoderms, and cuticular pattern defects in late-stage embryos. Transgenic expression of wild-type I-2 in mutant mothers gives dose-dependent rescue of the maternal effect on embryo hatch rate. We propose that I-2 is required for proper chromosome segregation during Drosophila embryogenesis through the coordinated regulation of PP1 and Aurora B. | lld:pubmed |
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| pubmed-article:18689877 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18689877 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18689877 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18689877 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18689877 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18689877 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:18689877 | pubmed:author | pubmed-author:BrautiganDavi... | lld:pubmed |
| pubmed-article:18689877 | pubmed:author | pubmed-author:WangWeipingW | lld:pubmed |
| pubmed-article:18689877 | pubmed:author | pubmed-author:CronmillerCla... | lld:pubmed |
| pubmed-article:18689877 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18689877 | pubmed:volume | 179 | lld:pubmed |
| pubmed-article:18689877 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18689877 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18689877 | pubmed:pagination | 1823-33 | lld:pubmed |
| pubmed-article:18689877 | pubmed:dateRevised | 2011-7-11 | lld:pubmed |
| pubmed-article:18689877 | pubmed:meshHeading | pubmed-meshheading:18689877... | lld:pubmed |
| pubmed-article:18689877 | pubmed:meshHeading | pubmed-meshheading:18689877... | lld:pubmed |
| pubmed-article:18689877 | pubmed:meshHeading | pubmed-meshheading:18689877... | lld:pubmed |
| pubmed-article:18689877 | pubmed:meshHeading | pubmed-meshheading:18689877... | lld:pubmed |
| pubmed-article:18689877 | pubmed:meshHeading | pubmed-meshheading:18689877... | lld:pubmed |
| pubmed-article:18689877 | pubmed:meshHeading | pubmed-meshheading:18689877... | lld:pubmed |
| pubmed-article:18689877 | pubmed:meshHeading | pubmed-meshheading:18689877... | lld:pubmed |
| pubmed-article:18689877 | pubmed:meshHeading | pubmed-meshheading:18689877... | lld:pubmed |
| pubmed-article:18689877 | pubmed:meshHeading | pubmed-meshheading:18689877... | lld:pubmed |
| pubmed-article:18689877 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18689877 | pubmed:articleTitle | Maternal phosphatase inhibitor-2 is required for proper chromosome segregation and mitotic synchrony during Drosophila embryogenesis. | lld:pubmed |
| pubmed-article:18689877 | pubmed:affiliation | Center for Cell Signaling and Department of Microbiology, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA. | lld:pubmed |
| pubmed-article:18689877 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18689877 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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