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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1991-9-18
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pubmed:abstractText |
The insulin regimen with two daily injections is still that more frequently used. Often regular and NPH insulins are mixed at different ratios according to the patient's need; however, the mixture preparation can involve several errors. Efficacy, safety and compliance were evaluated comparing a premixture 3/7 (Actraphane HM) with extemporary mixtures of regular + NPH at mixing ratios ranging from 2/8 to 4/6, in a cross-over study of 8 weeks involving 20 insulin dependent diabetics. Metabolic control, hypoglycaemic episodes, insulin dose and proportions were similar with both treatments while a higher compliance was achieved with the premixture. In conclusion, premixture 3/7 and extemporary mixture (from 2/8 to 4/6) obtain the same efficacy and safety but the former shows a higher acceptability.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Fructosamine,
http://linkedlifedata.com/resource/pubmed/chemical/Hexosamines,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin, Isophane
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pubmed:status |
MEDLINE
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pubmed:issn |
0338-1684
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
49-54
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1868960-Adult,
pubmed-meshheading:1868960-Aged,
pubmed-meshheading:1868960-Blood Glucose,
pubmed-meshheading:1868960-Diabetes Mellitus, Type 1,
pubmed-meshheading:1868960-Dose-Response Relationship, Drug,
pubmed-meshheading:1868960-Female,
pubmed-meshheading:1868960-Fructosamine,
pubmed-meshheading:1868960-Hexosamines,
pubmed-meshheading:1868960-Humans,
pubmed-meshheading:1868960-Insulin,
pubmed-meshheading:1868960-Insulin, Isophane,
pubmed-meshheading:1868960-Male,
pubmed-meshheading:1868960-Middle Aged
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pubmed:articleTitle |
Premixed insulin at ratio 3/7 and regular + isophane insulins at mixing ratios from 2/8 to 4/6 achieve the same metabolic control.
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pubmed:affiliation |
Istituto di Medicina Interna, Università di Messina, Italy.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Controlled Clinical Trial
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