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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-9-11
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pubmed:abstractText |
The main histological change in rheumatoid arthritis (RA) is the villous proliferation of synovial lining cells. This seems to be the result of the proliferation and apoptosis induced by immune balance. We studied the involvement of RCAS1 and the infiltration of cytotoxic T lymphocytes (CTL), and examined the synovium immunohistochemically to determine the involvement of proliferation and apoptosis in synovial lining cells, and their relationship with the activity of RATreg cells in the germinal center.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0315-162X
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pubmed:author |
pubmed-author:AokiRyosukeR,
pubmed-author:GotoMasafumiM,
pubmed-author:HashikawaKeikoK,
pubmed-author:HiguchiFujioF,
pubmed-author:IshibashiYumikoY,
pubmed-author:KarubeKennosukeK,
pubmed-author:KimuraYoshizoY,
pubmed-author:KomataniHidekiH,
pubmed-author:NagataKenseiK,
pubmed-author:NakashimaManabuM,
pubmed-author:NomuraYukoY,
pubmed-author:OhshimaKoichiK,
pubmed-author:ShimizuKeiK,
pubmed-author:SugitaYasuoY,
pubmed-author:YoshidaShiroS
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1716-22
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pubmed:meshHeading |
pubmed-meshheading:18688918-Antigens, Neoplasm,
pubmed-meshheading:18688918-Apoptosis,
pubmed-meshheading:18688918-Arthritis, Rheumatoid,
pubmed-meshheading:18688918-C-Reactive Protein,
pubmed-meshheading:18688918-Caspase 3,
pubmed-meshheading:18688918-Cell Proliferation,
pubmed-meshheading:18688918-Down-Regulation,
pubmed-meshheading:18688918-Forkhead Transcription Factors,
pubmed-meshheading:18688918-Germinal Center,
pubmed-meshheading:18688918-Humans,
pubmed-meshheading:18688918-Immunohistochemistry,
pubmed-meshheading:18688918-Ki-67 Antigen,
pubmed-meshheading:18688918-Synovial Membrane,
pubmed-meshheading:18688918-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:18688918-T-Lymphocytes, Regulatory,
pubmed-meshheading:18688918-Up-Regulation
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pubmed:year |
2008
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pubmed:articleTitle |
Downregulation of RCAS1 and upregulation of cytotoxic T cells affects synovial proliferation and apoptosis in rheumatoid arthritis.
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pubmed:affiliation |
Department of Pathology, School of Medicine, Kurume University, Kurume, Japan. marine7blue@hotmail.com
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pubmed:publicationType |
Journal Article
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