| pubmed-article:18685007 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18685007 | lifeskim:mentions | umls-concept:C0021344 | lld:lifeskim |
| pubmed-article:18685007 | lifeskim:mentions | umls-concept:C0043210 | lld:lifeskim |
| pubmed-article:18685007 | lifeskim:mentions | umls-concept:C0851140 | lld:lifeskim |
| pubmed-article:18685007 | lifeskim:mentions | umls-concept:C2347026 | lld:lifeskim |
| pubmed-article:18685007 | lifeskim:mentions | umls-concept:C0370003 | lld:lifeskim |
| pubmed-article:18685007 | lifeskim:mentions | umls-concept:C0010819 | lld:lifeskim |
| pubmed-article:18685007 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:18685007 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:18685007 | lifeskim:mentions | umls-concept:C0032520 | lld:lifeskim |
| pubmed-article:18685007 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:18685007 | lifeskim:mentions | umls-concept:C1415189 | lld:lifeskim |
| pubmed-article:18685007 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:18685007 | lifeskim:mentions | umls-concept:C1510438 | lld:lifeskim |
| pubmed-article:18685007 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:18685007 | pubmed:dateCreated | 2008-10-6 | lld:pubmed |
| pubmed-article:18685007 | pubmed:abstractText | Using a case control approach, we performed a two-way comparison study between GP5+/6+-PCR and HPV SPF(10)-Line Blot 25 (SPF(10)) assays for detection of 14 types of high-risk human papillomavirus (hrHPV) in samples from women with normal cytology results who had or developed grade 3 cervical intraepithelial neoplasia (CIN 3). Samples were pooled from two cohorts, i.e., women participating in population-based screening and women attending a gynecological outpatient clinic. Cases (n = 45) were women with histologically confirmed CIN 3 diagnosed within a median follow-up time of 2.7 (range, 0.2 to 7.9) years. Control samples were from women (n = 264) who had developed CIN 1 lesions at maximum (median follow-up at 5.8 [range, 0 to 10] years). Identical numbers of cases tested positive for 1 or more of the 14 hrHPV types by both systems (40/45; McNemar; P = 1.0). Conversely, SPF(10) scored significantly more controls as hrHPV positive than did GP5+/6+-PCR (95/264 versus 29/264; McNemar; P < 0.001). Consequently, women with normal cytology results and an hrHPV GP5+/6+-PCR-positive test exhibited a risk of CIN 3 that was 4.5 times higher (odds ratio [OR], 65; 95% confidence interval [95%CI], 24 to 178) than that seen for women with an hrHPV-positive SPF(10) test (OR, 14; 95%CI, 5 to 38)). Similar results were obtained after analysis of both cohorts separately. Discrepancy analysis by viral load assessment for the most common discordant hrHPV types (HPV16, -18, and -52) showed that samples which were SPF(10) positive only for these types had viral loads significantly lower than those for samples that were positive by both assays (analysis of variance; P < or = 0.006). Our data indicate that GP5+/6+-PCR has a better clinical performance than SPF(10) for women who are diagnosed with CIN 3 after prior normal cytology results. The extra positivity scored by SPF(10) mainly involved infections characterized by low viral loads that do not result in CIN 3. | lld:pubmed |
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| pubmed-article:18685007 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18685007 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18685007 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18685007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18685007 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18685007 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:18685007 | pubmed:issn | 1098-660X | lld:pubmed |
| pubmed-article:18685007 | pubmed:author | pubmed-author:RozendaalLL | lld:pubmed |
| pubmed-article:18685007 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:18685007 | pubmed:author | pubmed-author:BerkhofJJ | lld:pubmed |
| pubmed-article:18685007 | pubmed:author | pubmed-author:SnijdersP J... | lld:pubmed |
| pubmed-article:18685007 | pubmed:author | pubmed-author:MeijerC J L... | lld:pubmed |
| pubmed-article:18685007 | pubmed:author | pubmed-author:MelchersW J... | lld:pubmed |
| pubmed-article:18685007 | pubmed:author | pubmed-author:van HamM A... | lld:pubmed |
| pubmed-article:18685007 | pubmed:author | pubmed-author:HeidemanD A... | lld:pubmed |
| pubmed-article:18685007 | pubmed:author | pubmed-author:HesselinkA... | lld:pubmed |
| pubmed-article:18685007 | pubmed:author | pubmed-author:Groothuismink... | lld:pubmed |
| pubmed-article:18685007 | pubmed:author | pubmed-author:MassugerL A... | lld:pubmed |
| pubmed-article:18685007 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18685007 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:18685007 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18685007 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18685007 | pubmed:pagination | 3215-21 | lld:pubmed |
| pubmed-article:18685007 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:18685007 | pubmed:meshHeading | pubmed-meshheading:18685007... | lld:pubmed |
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| pubmed-article:18685007 | pubmed:meshHeading | pubmed-meshheading:18685007... | lld:pubmed |
| pubmed-article:18685007 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18685007 | pubmed:articleTitle | Comparison of GP5+/6+-PCR and SPF10-line blot assays for detection of high-risk human papillomavirus in samples from women with normal cytology results who develop grade 3 cervical intraepithelial neoplasia. | lld:pubmed |
| pubmed-article:18685007 | pubmed:affiliation | Department of Pathology, VU University Medical Center, de Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:18685007 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18685007 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:18685007 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18685007 | pubmed:publicationType | Evaluation Studies | lld:pubmed |
