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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2008-8-29
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pubmed:abstractText |
In order to find an injectable and selective N-type calcium channel blocker, we have performed the structure-activity relationship (SAR) study on the 2-, 5-, and 6-position of 1,4-dihydropyridine-3-carboxylate derivative APJ2708 (2), which is a derivative of Cilnidipine and has L/N-type calcium channel dual inhibitory activities. As a consequence of the optimization, 6-dimethylacetal derivative 7 was found to have an effective inhibitory activity against N-type calcium channels with more than 170-fold lower activity for L-type channel compared to that of APJ2708.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:FujitaShin-IchiS,
pubmed-author:IwataSeinosukeS,
pubmed-author:KitoMorikazuM,
pubmed-author:KoganeiHajimeH,
pubmed-author:MasuzawaYokoY,
pubmed-author:NakajoAkiraA,
pubmed-author:NakanishiChikaC,
pubmed-author:NiwaSeijiS,
pubmed-author:OhnoSeijiS,
pubmed-author:OnishiTomoyukiT,
pubmed-author:OnoYukitsuguY,
pubmed-author:SaitouYukiY,
pubmed-author:ShojiMasatakaM,
pubmed-author:TakaharaAkiraA,
pubmed-author:TakedaTomokoT,
pubmed-author:TokumasuMunetakaM,
pubmed-author:YamamotoTakashiT
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
18
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
4813-6
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pubmed:meshHeading |
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pubmed:year |
2008
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pubmed:articleTitle |
The structure-activity relationship study on 2-, 5-, and 6-position of the water soluble 1,4-dihydropyridine derivatives blocking N-type calcium channels.
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pubmed:affiliation |
Pharmaceutical Research Laboratory, Ajinomoto company Inc., 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-shi, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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