| pubmed-article:1867967 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1867967 | lifeskim:mentions | umls-concept:C0001792 | lld:lifeskim |
| pubmed-article:1867967 | lifeskim:mentions | umls-concept:C2349001 | lld:lifeskim |
| pubmed-article:1867967 | lifeskim:mentions | umls-concept:C0681850 | lld:lifeskim |
| pubmed-article:1867967 | lifeskim:mentions | umls-concept:C1706203 | lld:lifeskim |
| pubmed-article:1867967 | lifeskim:mentions | umls-concept:C2697811 | lld:lifeskim |
| pubmed-article:1867967 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:1867967 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:1867967 | lifeskim:mentions | umls-concept:C0029997 | lld:lifeskim |
| pubmed-article:1867967 | lifeskim:mentions | umls-concept:C0178602 | lld:lifeskim |
| pubmed-article:1867967 | lifeskim:mentions | umls-concept:C0851347 | lld:lifeskim |
| pubmed-article:1867967 | lifeskim:mentions | umls-concept:C1550501 | lld:lifeskim |
| pubmed-article:1867967 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:1867967 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1867967 | pubmed:dateCreated | 1991-9-13 | lld:pubmed |
| pubmed-article:1867967 | pubmed:abstractText | The effect of extreme old age on the pharmacokinetics and pharmacodynamics of orally administered oxazepam 15 mg was studied in 10 healthy elderly (age 80-94 years) institutionalised subjects and 10 healthy young controls (age 26-42 years). The total oxazepam clearance was 1.24 (0.91-1.80) ml min-1 kg-1 (median and range) and 1.44 (0.88-2.13) ml min-1 kg-1 in the elderly and young, respectively (NS), and the elimination half-lives were 8.1 (5.5-10.8) h and 5.7 (4.9-6.2) h. respectively (P less than 0.01). The percent of unbound oxazepam was greater in the elderly; 9.8 (8.1-13.3)% as opposed to 5.1 (3.7-5.9)% in the young (P less than 0.0001). Clearance of unbound oxazepam was lower in the elderly, median values being 13.8 (7.1-21.1) ml min-1 kg-1 compared with 30.3 (18.3-41.5) ml min-1 kg-1 in the young (P less than 0.0001). A single 15 mg dose oxazepam decreased the ability of the elderly to perform a finger tapping test at 3 h but not 8 h after drug administration, whereas placebo had no effect at either times. No effect was observed in the young subjects. | lld:pubmed |
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| pubmed-article:1867967 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1867967 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1867967 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1867967 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1867967 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1867967 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1867967 | pubmed:issn | 0306-5251 | lld:pubmed |
| pubmed-article:1867967 | pubmed:author | pubmed-author:DøssingMM | lld:pubmed |
| pubmed-article:1867967 | pubmed:author | pubmed-author:AndreasenFF | lld:pubmed |
| pubmed-article:1867967 | pubmed:author | pubmed-author:SonneJJ | lld:pubmed |
| pubmed-article:1867967 | pubmed:author | pubmed-author:LoftSS | lld:pubmed |
| pubmed-article:1867967 | pubmed:author | pubmed-author:BoesgaardSS | lld:pubmed |
| pubmed-article:1867967 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1867967 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:1867967 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1867967 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1867967 | pubmed:pagination | 719-22 | lld:pubmed |
| pubmed-article:1867967 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1867967 | pubmed:meshHeading | pubmed-meshheading:1867967-... | lld:pubmed |
| pubmed-article:1867967 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1867967 | pubmed:articleTitle | Single dose pharmacokinetics and pharmacodynamics of oral oxazepam in very elderly institutionalised subjects. | lld:pubmed |
| pubmed-article:1867967 | pubmed:affiliation | Department of Medicine, Hvidovre Hospital, Denmark. | lld:pubmed |
| pubmed-article:1867967 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1867967 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:1867967 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:1867967 | pubmed:publicationType | Controlled Clinical Trial | lld:pubmed |
