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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001792,
umls-concept:C0029997,
umls-concept:C0031327,
umls-concept:C0178602,
umls-concept:C0205171,
umls-concept:C0442027,
umls-concept:C0681850,
umls-concept:C0851347,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C2349001,
umls-concept:C2697811
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pubmed:issue |
6
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|
pubmed:dateCreated |
1991-9-13
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pubmed:abstractText |
The effect of extreme old age on the pharmacokinetics and pharmacodynamics of orally administered oxazepam 15 mg was studied in 10 healthy elderly (age 80-94 years) institutionalised subjects and 10 healthy young controls (age 26-42 years). The total oxazepam clearance was 1.24 (0.91-1.80) ml min-1 kg-1 (median and range) and 1.44 (0.88-2.13) ml min-1 kg-1 in the elderly and young, respectively (NS), and the elimination half-lives were 8.1 (5.5-10.8) h and 5.7 (4.9-6.2) h. respectively (P less than 0.01). The percent of unbound oxazepam was greater in the elderly; 9.8 (8.1-13.3)% as opposed to 5.1 (3.7-5.9)% in the young (P less than 0.0001). Clearance of unbound oxazepam was lower in the elderly, median values being 13.8 (7.1-21.1) ml min-1 kg-1 compared with 30.3 (18.3-41.5) ml min-1 kg-1 in the young (P less than 0.0001). A single 15 mg dose oxazepam decreased the ability of the elderly to perform a finger tapping test at 3 h but not 8 h after drug administration, whereas placebo had no effect at either times. No effect was observed in the young subjects.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-1127104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-2373130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-2574189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-2664519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-2737234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-28871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-3197746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-36252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-3759915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-6102508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-630787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-6691478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-6772370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-680505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-6849765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-7040951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-722481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-7278081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-7357789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-7452494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-759470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-769632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1867967-925190
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0306-5251
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
719-22
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1867967-Administration, Oral,
pubmed-meshheading:1867967-Adult,
pubmed-meshheading:1867967-Aged,
pubmed-meshheading:1867967-Aged, 80 and over,
pubmed-meshheading:1867967-Aging,
pubmed-meshheading:1867967-Female,
pubmed-meshheading:1867967-Half-Life,
pubmed-meshheading:1867967-Humans,
pubmed-meshheading:1867967-Institutionalization,
pubmed-meshheading:1867967-Male,
pubmed-meshheading:1867967-Oxazepam,
pubmed-meshheading:1867967-Psychomotor Performance
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pubmed:year |
1991
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pubmed:articleTitle |
Single dose pharmacokinetics and pharmacodynamics of oral oxazepam in very elderly institutionalised subjects.
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pubmed:affiliation |
Department of Medicine, Hvidovre Hospital, Denmark.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, Non-P.H.S.,
Controlled Clinical Trial
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