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pubmed-article:18679125pubmed:abstractTextHigh B-type natriuretic peptide (BNP) levels are reported in the context of septic shock. We hypothesized that high BNP levels might be related to an alteration in BNP clearance pathway, namely neutral endopeptidase (NEP) 24.11. NEP 24.11 activity was measured in septic shock and in cardiogenic shock patients. We further evaluated whether baseline plasma BNP can predict fluid responsiveness and whether BNP can still be released in plasma despite high initial BNP levels, in response to overloading.lld:pubmed
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pubmed-article:18679125pubmed:articleTitleImpaired plasma B-type natriuretic peptide clearance in human septic shock.lld:pubmed
pubmed-article:18679125pubmed:affiliationDepartment of Anesthesiology and Critical Care Medicine, Lariboisière Hospital, APHP, University Paris 7 Diderot, Paris, France. romainpirracchio@yahoo.frlld:pubmed
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