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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0010453,
umls-concept:C0035820,
umls-concept:C0037663,
umls-concept:C0041014,
umls-concept:C0205263,
umls-concept:C0206588,
umls-concept:C0332120,
umls-concept:C0333668,
umls-concept:C0596715,
umls-concept:C1333673,
umls-concept:C1512045
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pubmed:issue |
11
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pubmed:dateCreated |
1977-1-29
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pubmed:abstractText |
The relationship between the binding of L-triiodothyronine (T3) to nuclear receptors and the induction of growth hormone synthesis was examined in cultured GH1 cells, a rat pituitary cell line. After 24 hr, T3 induced a maximal 4-fold increase in the rate of growth hormone wynthesis; the T3 concentration that induced a half-maximal increase was 0.22 nM. The biologic dose-response curve was shifted to the left of the receptor occupancy curve (Kd = 0.5 nM) by a factor of approximately 2 when receptor binding was examined for 4 hr but showed a significantly closer agreement when examined for the same 24-hr period as the biologic response. This shift in the fractional occupancy curve is not due to further equilibration but occurs as a result of a time- and dose-dependent depletion of the nuclear receptor by T3.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/186776-11344581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/186776-13293190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/186776-167023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/186776-169242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/186776-171134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/186776-180007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/186776-185609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/186776-236310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/186776-4357872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/186776-4359334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/186776-4372251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/186776-4512325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/186776-4737760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/186776-4812438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/186776-4835871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/186776-4858353
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3877-81
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1976
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pubmed:articleTitle |
Dose-dependent depletion of nuclear receptors by L-triiodothyronine: evidence for a role in induction of growth hormone synthesis in cultured GH1 cells.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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