| pubmed-article:18677302 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18677302 | lifeskim:mentions | umls-concept:C1514428 | lld:lifeskim |
| pubmed-article:18677302 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
| pubmed-article:18677302 | lifeskim:mentions | umls-concept:C1520751 | lld:lifeskim |
| pubmed-article:18677302 | lifeskim:mentions | umls-concept:C1101610 | lld:lifeskim |
| pubmed-article:18677302 | lifeskim:mentions | umls-concept:C1704332 | lld:lifeskim |
| pubmed-article:18677302 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18677302 | pubmed:dateCreated | 2009-1-30 | lld:pubmed |
| pubmed-article:18677302 | pubmed:abstractText | MicroRNAs are a group of small non-coding RNAs approximately 22 nucleotides in length. Recent work has shown differential expression of mature microRNAs in human cancers. We characterized the alteration in expression of a select group of microRNAs in primary peritoneal carcinoma relative to matched cases of ovarian serous carcinoma. MicroRNA expression was analysed using semi-quantitative stem-loop RT-PCR on a set of 34 formalin-fixed paraffin-embedded samples. Protein expression of p53 and bcl-2 was quantified in the corresponding tissue microarray. We provide definitive evidence that there is downregulation of a select group of microRNAs in tumours meeting Gynaecological Oncology Group criteria for primary peritoneal carcinoma relative to ovarian serous carcinoma. Specifically, we show decreased p53 expression and downregulation of miR-195 and miR-497 from the microRNA cluster site at chromosome 17p13.1 in primary peritoneal carcinoma relative to ovarian serous carcinoma. miR-195 and miR-497 may have potential roles as tumour-suppressor genes in primary peritoneal tumourigenesis. | lld:pubmed |
| pubmed-article:18677302 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18677302 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18677302 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18677302 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18677302 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18677302 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:18677302 | pubmed:issn | 1530-0285 | lld:pubmed |
| pubmed-article:18677302 | pubmed:author | pubmed-author:LewM JMJ | lld:pubmed |
| pubmed-article:18677302 | pubmed:author | pubmed-author:O'LearyJohn... | lld:pubmed |
| pubmed-article:18677302 | pubmed:author | pubmed-author:RussellSusanS | lld:pubmed |
| pubmed-article:18677302 | pubmed:author | pubmed-author:FinnStephen... | lld:pubmed |
| pubmed-article:18677302 | pubmed:author | pubmed-author:O'TooleSharon... | lld:pubmed |
| pubmed-article:18677302 | pubmed:author | pubmed-author:SheppardBrian... | lld:pubmed |
| pubmed-article:18677302 | pubmed:author | pubmed-author:RingMartinaM | lld:pubmed |
| pubmed-article:18677302 | pubmed:author | pubmed-author:BarrettCiaraC | lld:pubmed |
| pubmed-article:18677302 | pubmed:author | pubmed-author:SheilsOrla... | lld:pubmed |
| pubmed-article:18677302 | pubmed:author | pubmed-author:SmythPaul CPC | lld:pubmed |
| pubmed-article:18677302 | pubmed:author | pubmed-author:LiJinghuanJ | lld:pubmed |
| pubmed-article:18677302 | pubmed:author | pubmed-author:DenningKaren... | lld:pubmed |
| pubmed-article:18677302 | pubmed:author | pubmed-author:FlavinRichard... | lld:pubmed |
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| pubmed-article:18677302 | pubmed:author | pubmed-author:SammaraeDania... | lld:pubmed |
| pubmed-article:18677302 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18677302 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:18677302 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18677302 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18677302 | pubmed:pagination | 197-205 | lld:pubmed |
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| pubmed-article:18677302 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:18677302 | pubmed:articleTitle | Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma. | lld:pubmed |
| pubmed-article:18677302 | pubmed:affiliation | Department of Histopathology, Trinity College Dublin, Dublin, Ireland. flavinr@tcd.ie | lld:pubmed |
| pubmed-article:18677302 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18677302 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:18677302 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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