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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2008-8-25
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pubmed:abstractText |
Interleukin-22 (IL-22) is a member of the interleukin-10 cytokine family, which is involved in anti-microbial defenses, tissue damage protection and repair, and acute phase responses. Its signaling mechanism involves the sequential binding of IL-22 to interleukin-22 receptor 1 (IL-22R1), and of this dimer to interleukin-10 receptor 2 (IL-10R2) extracellular domain. We report a 1.9A crystal structure of the IL-22/IL-22R1 complex, revealing crucial interacting residues at the IL-22/IL-22R1 interface. Functional importance of key residues was confirmed by site-directed mutagenesis and functional studies. Based on the X-ray structure of the binary complex, we discuss a molecular basis of the IL-22/IL-22R1 recognition by IL-10R2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
582
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2985-92
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pubmed:meshHeading |
pubmed-meshheading:18675809-Amino Acid Sequence,
pubmed-meshheading:18675809-Cell Line,
pubmed-meshheading:18675809-Crystallography, X-Ray,
pubmed-meshheading:18675809-Humans,
pubmed-meshheading:18675809-Interleukins,
pubmed-meshheading:18675809-Molecular Sequence Data,
pubmed-meshheading:18675809-Mutation,
pubmed-meshheading:18675809-Protein Conformation,
pubmed-meshheading:18675809-Receptors, Interleukin,
pubmed-meshheading:18675809-Receptors, Interleukin-10,
pubmed-meshheading:18675809-Signal Transduction
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pubmed:year |
2008
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pubmed:articleTitle |
Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism.
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pubmed:affiliation |
Instituto de Física de São Carlos, Universidade de São Paulo, CEP 13560-970 São Carlos, SP, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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