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rdf:type |
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lifeskim:mentions |
umls-concept:C0078058,
umls-concept:C0086418,
umls-concept:C0225336,
umls-concept:C0262950,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0449438,
umls-concept:C1171892,
umls-concept:C1235660,
umls-concept:C1257975,
umls-concept:C1540661,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1820288
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pubmed:issue |
19
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pubmed:dateCreated |
2008-8-12
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pubmed:abstractText |
Human bone mesenchymal stem cells (hMSCs) can differentiate into endothelial cells (ECs), so we aimed to investigate whether hMSCs could also differentiate into a specific arterial or venous ECs. hMSCs were induced to differentiate into ECs using vascular endothelial growth factor (VEGF). Low VEGF concentration (50 ng/ml) upregulated the venous marker gene EphB4, however high concentration (100 ng/ml) upregulated the arterial marker genes ephrinB2, Dll4 and Notch4, and downregulated the venous marker genes EphB4 and COUP-TFll. This VEGF dose-dependent induction was largely blocked by inhibition of the Notch pathway in hMSCs treated with gamma-secretase inhibitor. Therefore, differentiation of hMSCs into arterial- or venous-specific ECs depends on VEGF and is regulated by the Notch pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid Precursor Protein Secretases,
http://linkedlifedata.com/resource/pubmed/chemical/COUP Transcription Factor II,
http://linkedlifedata.com/resource/pubmed/chemical/DLL4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ephrin-B2,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/NOTCH4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/NR2F2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, EphB4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Notch,
http://linkedlifedata.com/resource/pubmed/chemical/VEGFA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
582
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2957-64
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18671974-Amyloid Precursor Protein Secretases,
pubmed-meshheading:18671974-Arteries,
pubmed-meshheading:18671974-Bone and Bones,
pubmed-meshheading:18671974-COUP Transcription Factor II,
pubmed-meshheading:18671974-Cell Culture Techniques,
pubmed-meshheading:18671974-Cell Differentiation,
pubmed-meshheading:18671974-Child,
pubmed-meshheading:18671974-Child, Preschool,
pubmed-meshheading:18671974-Endothelium, Vascular,
pubmed-meshheading:18671974-Ephrin-B2,
pubmed-meshheading:18671974-Gene Expression,
pubmed-meshheading:18671974-Gene Expression Regulation,
pubmed-meshheading:18671974-Humans,
pubmed-meshheading:18671974-Infant,
pubmed-meshheading:18671974-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:18671974-Mesenchymal Stem Cells,
pubmed-meshheading:18671974-Neovascularization, Physiologic,
pubmed-meshheading:18671974-Proto-Oncogene Proteins,
pubmed-meshheading:18671974-Receptor, EphB4,
pubmed-meshheading:18671974-Receptors, Notch,
pubmed-meshheading:18671974-Up-Regulation,
pubmed-meshheading:18671974-Vascular Endothelial Growth Factor A,
pubmed-meshheading:18671974-Veins
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pubmed:year |
2008
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pubmed:articleTitle |
Arterial-venous endothelial cell fate is related to vascular endothelial growth factor and Notch status during human bone mesenchymal stem cell differentiation.
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pubmed:affiliation |
Department of Cardiac Surgery, Shandong Provincial Hospital, Shandong University, Jingwu Road 324, Jinan, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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