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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
31
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pubmed:dateCreated |
2008-8-6
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pubmed:abstractText |
Huntington's disease is a dominant autosomal neurodegenerative disorder caused by an expansion of polyglutamines in the huntingtin (Htt) protein, whose cellular function remains controversial. To gain insight into Htt function, we purified epitope-tagged Htt and identified Argonaute as associated proteins. Colocalization studies demonstrated Htt and Ago2 to be present in P bodies, and depletion of Htt showed compromised RNA-mediated gene silencing. Mouse striatal cells expressing mutant Htt showed fewer P bodies and reduced reporter gene silencing activity compared with wild-type counterparts. These data suggest that the previously reported transcriptional deregulation in HD may be attributed in part to mutant Htt's role in post-transcriptional processes.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1091-6490
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10820-5
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18669659-Argonaute Proteins,
pubmed-meshheading:18669659-Cytoplasmic Structures,
pubmed-meshheading:18669659-Eukaryotic Initiation Factor-2,
pubmed-meshheading:18669659-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:18669659-Humans,
pubmed-meshheading:18669659-MicroRNAs,
pubmed-meshheading:18669659-Microscopy, Confocal,
pubmed-meshheading:18669659-Nerve Tissue Proteins,
pubmed-meshheading:18669659-Nuclear Proteins,
pubmed-meshheading:18669659-RNA Interference
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pubmed:year |
2008
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pubmed:articleTitle |
Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies.
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pubmed:affiliation |
Department of Microbiology and New York University Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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