Linked Life Data

18668157

Source:http://linkedlifedata.com/resource/pubmed/id/18668157

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-7-31
pubmed:abstractText
Nigrostriatal neurons expressing RET protein, a receptor protein tyrosine kinase of glial cell line-derived neurotrophic factor (GDNF) were investigated in rats using retrograde neural tracing with horseradish peroxidase (HRP) combined with immunohistochemistry. HR/RET double-labeled neurons were abundantly distributed in the substantia nigra pars compacta ipsilateral to the caudate-putamen stereotaxically injected with HRP. Almost all the HRP-labeled neurons in nigra exhibited RET-like immunoreactivity, which however constituted more than half of the RET-immunoreactive cells. Our results present morphological evidence that GDNF-RET interaction plays important roles in physiological processes of nigrostriatal neuronal circuits of mammals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-1400
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
347-53
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Nigrostriatal projecting neurons express GDNF receptor subunit RET in adult rats.
pubmed:affiliation
Department of Neurosurgery, Institute for functional neurosurgery P.L.A, TangDu Hospital, Fourth Military Medical University, Xiian, P.R. China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't